Therapeutic potential of Brazilian green propolis and oregano (Origanum vulgare) extracts in collagen hydrogel for pressure ulcer repair: an experimental study in an animal model.
Jhuan Luiz Silva, Eveline Maria de Melo, Antonio Augusto Borges Sales, Thaylla Maria Ferreira, Lauany Mazzon Pontes, Fernanda Gosuen Gonçalves Dias, Sergio Ricardo Ambrosio, Wilson Roberto Cunha, Marcela Aldrovani Rodrigues
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Abstract
This study investigated the effects of incorporating Brazilian green propolis ethanolic extract and oregano (Origanum vulgare) methanolic extract into type I collagen hydrogel to enhance pressure ulcer healing in mice. Forty-four mice were divided into four groups: untreated control, plain collagen hydrogel, collagen hydrogel with 1% green propolis extract, and collagen hydrogel with 1% oregano extract. Pressure ulcers were induced on their dorsal skin, followed by a 14-day assessment of wound area, contraction, re-epithelialization, dermal collagen density, and levels of reactive oxygen species and nitrite. Results showed significant tissue repair promotion by both propolis and oregano extracts, with oregano exhibiting superior wound contraction. These hydrogels also facilitated skin layer reorganisation and reduced reactive oxygen species and nitrite production. Collagen hydrogels containing these extracts show promising therapeutic potential for pressure ulcer treatment.
期刊介绍：
The aim of Natural Product Research is to publish important contributions in the field of natural product chemistry. The journal covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds.
The communications include coverage of work on natural substances of land and sea and of plants, microbes and animals. Discussions of structure elucidation, synthesis and experimental biosynthesis of natural products as well as developments of methods in these areas are welcomed in the journal. Finally, research papers in fields on the chemistry-biology boundary, eg. fermentation chemistry, plant tissue culture investigations etc., are accepted into the journal.
Natural Product Research issues will be subtitled either ""Part A - Synthesis and Structure"" or ""Part B - Bioactive Natural Products"". for details on this , see the forthcoming articles section.
All manuscript submissions are subject to initial appraisal by the Editor, and, if found suitable for further consideration, to peer review by independent, anonymous expert referees. All peer review is single blind and submission is online via ScholarOne Manuscripts.
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