{"title":"[Autoimmune thyroid disease in children and adolescents].","authors":"Sophie Stoppa-Vaucher, Mirjam Dirlewanger","doi":"10.53738/REVMED.2025.21.906.320","DOIUrl":null,"url":null,"abstract":"<p><p>Autoimmune thyroid diseases, including Hashimoto's thyroiditis and Graves' disease, are the most common causes of acquired thyroid dysfunction in children and adolescents. They are often diagnosed at puberty, with a female predominance. A familial predisposition and associations with other autoimmune diseases such as celiac disease and type 1 diabetes point to underlying genetic mechanisms. This predisposition is attributed to the polymorphism of multiple HLA (Human Leukocyte Antigen) and non-HLA susceptibility genes, opening the field for the development of targeted therapies that can potentially modify the course and prognosis of autoimmune thyroid diseases.</p>","PeriodicalId":21286,"journal":{"name":"Revue medicale suisse","volume":"21 906","pages":"320-325"},"PeriodicalIF":0.0000,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Revue medicale suisse","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.53738/REVMED.2025.21.906.320","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Medicine","Score":null,"Total":0}
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Abstract
Autoimmune thyroid diseases, including Hashimoto's thyroiditis and Graves' disease, are the most common causes of acquired thyroid dysfunction in children and adolescents. They are often diagnosed at puberty, with a female predominance. A familial predisposition and associations with other autoimmune diseases such as celiac disease and type 1 diabetes point to underlying genetic mechanisms. This predisposition is attributed to the polymorphism of multiple HLA (Human Leukocyte Antigen) and non-HLA susceptibility genes, opening the field for the development of targeted therapies that can potentially modify the course and prognosis of autoimmune thyroid diseases.
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