I Caroline Vaaland Holmgard, Idd Andrea Christensen, Ljupcho Pejov, Monika Moreń, Nikolai Westlund, Tereza Cristina Santos Evangelista, Magne O Sydnes, Finn L Aachmann, Óscar López, Emil Lindbäck
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引用次数: 0
Abstract
The synthesis of an isofagomine analogue with an amidine group in the 1,6-position is described. Density functional theory calculations showed that this compound has a remarkably different charge distribution compared with isofagomine. This may explain why the amidine is a poor glycosidase inhibitor (IC50 > 50 µM against all tested enzymes) compared with isofagomine.
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