Role of anti-inflammatory cytokine (IL10) in patients with chronic kidney disease.

Q3 Medicine Human Antibodies Pub Date : 2025-05-01 Epub Date: 2025-02-12 DOI:10.1177/10932607251317417

Duaa Mohammed Abdulsatar, Hayfaa Mahmood Fahad, Sahar Taha Hatif, Zaid Jaafar Awad Al-Nuaimi

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Abstract

BackgroundAnti-inflammatory cytokines is thought to influence the onset and course of chronic kidney disease (CKD). Particular cytokines include Interleukin-10 (IL-10), which is usually considered anti-inflammatory.ObjectivesThe current study designed to determine the activity of the IL10 and their roles in chronic kidney disease.MethodsThis research is done, forty- five blood samples were collected from patients with chronic kidney disease and 42 volunteers. A sandwich ELISA was used to estimate the serum levels of human Interleukin-10.ResultsThe mean age among patient groups (males, females) it was 47.40 ± 2.96 and 62.64 ± 14.46 years, respectively. While the control groups (males, females) were 40.97 ± 1.67 and 45.25 ± 7.13 years (p > 0.05). Of the 45 patients, 20 (44.4%) were males, 25 (55.6%) females. The resulted data showed that there are no significant (p > 0.05) for the total of the mean of human IL-10 between patients and control, respectively, where the mean level of IL10 in males was 190.10 ± 15.07& 154.18 ± 8.77 (p < 0.05) respectively and 142.22 ± 12.43 & 117.04 ± 14.66 in females, but not significantly (p > 0.05), and revealed an highly increased significant in this marker during the course of the chronic kidney disease in males more than females in patients (p < 0.05).ConclusionCan conclude from this study that decreased anti-inflammatory cytokine IL10 likely affects CKD progression and prognosis in females specifically.

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抗炎细胞因子（IL10）在慢性肾病患者中的作用

背景：抗炎细胞因子被认为影响慢性肾脏疾病（CKD）的发病和病程。特殊的细胞因子包括白细胞介素-10 (IL-10)，它通常被认为是抗炎的。目的：本研究旨在确定il - 10的活性及其在慢性肾脏疾病中的作用。方法：采集45例慢性肾病患者和42名志愿者的血液样本进行研究。采用夹心ELISA法测定血清白细胞介素-10水平。结果：两组患者的平均年龄（男、女）分别为47.40±2.96岁和62.64±14.46岁。对照组（男、女）分别为40.97±1.67岁和45.25±7.13岁（p < 0.05）。其中男性20例（44.4%），女性25例（55.6%）。结果显示，患者与对照组之间IL-10的总平均值差异无统计学意义（p < 0.05），其中男性患者IL-10的平均值分别为190.10±15.07和154.18±8.77 (p < 0.05)，且在慢性肾病病程中，该标志物在男性患者中显著高于女性患者（p < 0.05）。从本研究可以得出结论，抗炎细胞因子IL10的降低可能特异性地影响女性CKD的进展和预后。

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来源期刊

Human Antibodies Medicine-Immunology and Allergy

CiteScore

3.50

自引率

0.00%

发文量

期刊介绍： Human Antibodies is an international journal designed to bring together all aspects of human hybridomas and antibody technology under a single, cohesive theme. This includes fundamental research, applied science and clinical applications. Emphasis in the published articles is on antisera, monoclonal antibodies, fusion partners, EBV transformation, transfections, in vitro immunization, defined antigens, tissue reactivity, scale-up production, chimeric antibodies, autoimmunity, natural antibodies/immune response, anti-idiotypes, and hybridomas secreting interesting growth factors. Immunoregulatory molecules, including T cell hybridomas, will also be featured.