The absolute volume of Gleason Pattern 4 on radical prostatectomy is more strongly associated with advanced stage and biochemical recurrence than Gleason grade groups.

Simone Scuderi, Amy L Tin, Jared Klug, Shaun Porwal, Leonardo Quarta, Margherita Ciabattini, Nazario Pio Tenace, Riccardo Leni, Roberta Lucianò, Armando Stabile, Giorgio Gandaglia, James A Eastham, Francesco Montorsi, Alberto Briganti, Andrew J Vickers
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Abstract

ISUP Grade-Group (GG) is based on the relative proportion of Gleason patterns 3 and 4. We investigated whether absolute pattern 4 volume is more strongly associated with advanced stage and biochemical recurrence than GG in patients with pattern 4 but not 5.
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The absolute volume of Gleason Pattern 4 on radical prostatectomy is more strongly associated with advanced stage and biochemical recurrence than Gleason grade groups. Retroperitoneal Nodal Distribution for Metastatic Seminoma: Is Modified Template Appropriate? A Retrospective Study. Primary Chemoablation of Recurrent Low-Grade Intermediate-Risk Nonmuscle-Invasive Bladder Cancer With UGN-102: A Single-Arm, Open-Label, Phase 3 Trial (ENVISION). Reply: Letter: Efficacy and Safety of Vibegron for Persistent Symptoms of Overactive Bladder in Men Being Pharmacologically Treated for Benign Prostatic Hyperplasia: Results From the Phase 3 COURAGE Trial. Reviewer of the Month: Geoffrey Sonn.
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