Sachin Balaso Mohite, Partha Sarathi Bera, Yafia Kousin Mirza, Vusisizwe Ntuli, Yugendhar Soorni, Rajshekhar Karpoormath, Milan Bera
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引用次数: 0
Abstract
Hexafluoroisopropanol (HFIP)-mediated terminal selective heteroarylation of allenamides has been accomplished through H-bonding network-enabled substrate activation in a robust fashion. This strategy features a cascade process involving sequential nucleophilic addition followed by electrophilic heteroaromatic substitution and is well suited for late-stage functionalization of complex bioactive molecules. The elucidation of the underlying mechanism was achieved through a comprehensive combination of several control experiments, kinetic studies, isotopic labeling experiments, and the isolation of the HFIP–allenamide intermediate adduct.
期刊介绍：
Organic Letters invites original reports of fundamental research in all branches of the theory and practice of organic, physical organic, organometallic,medicinal, and bioorganic chemistry. Organic Letters provides rapid disclosure of the key elements of significant studies that are of interest to a large portion of the organic community. In selecting manuscripts for publication, the Editors place emphasis on the originality, quality and wide interest of the work. Authors should provide enough background information to place the new disclosure in context and to justify the rapid publication format. Back-to-back Letters will be considered. Full details should be reserved for an Article, which should appear in due course.
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