The Relationship between OCD and Depression in Adults: A Review of Recent Findings.

IF 6.7 2区医学 Q1 PSYCHIATRY Current Psychiatry Reports Pub Date : 2025-04-01 Epub Date: 2025-02-21 DOI:10.1007/s11920-025-01589-6

Martin Pastre, Stéphane Raffard, Luc Mallet, Jorge Lopez-Castroman

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Abstract

Purpose of review: We aimed to investigate the recent understanding of the frequent coexistence of obsessive-compulsive disorder (OCD) and major depression (MDD), exploring both clinical and mechanistic perspectives. Our focus was on deriving conclusions with therapeutic implications.

Recent findings: While biological factors contribute to the development of OCD-MDD, the comorbidity seems to be primarily induced by the convergence of symptoms that complicate the course of OCD. Tailored cognitive-behavioral therapy programs, specifically addressing MDD, alongside SSRI medication, may prove beneficial for patients experiencing moderate to severe forms of this comorbidity. The review underscores the significance of comorbidity from both diagnostic and therapeutic perspectives. However, existing research has yet to offer a clear understanding of the underlying mechanisms. Further research in the field, notably coming from network studies, could enrich our practice by helping to target specific dimensions that underly OCD-MDD comorbidity.

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成人强迫症与抑郁症的关系：近期研究综述

回顾目的：我们旨在调查最近对强迫症（OCD）和重度抑郁症（MDD）频繁共存的理解，从临床和机制角度进行探讨。我们的重点是得出具有治疗意义的结论。最近的研究发现：虽然生物学因素有助于强迫症-重度抑郁症的发展，但共病似乎主要是由使强迫症病程复杂化的症状的融合引起的。量身定制的认知行为治疗方案，特别是针对重度抑郁症，与SSRI药物一起，可能对经历中度至重度这种合并症的患者有益。这篇综述强调了合并症在诊断和治疗方面的重要性。然而，现有的研究尚未提供对潜在机制的清晰理解。该领域的进一步研究，特别是来自网络的研究，可以通过帮助确定强迫症-重度抑郁症合并症的具体维度来丰富我们的实践。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Psychiatry Reports PSYCHIATRY-

CiteScore

11.30

自引率

3.00%

发文量

审稿时长

6-12 weeks

期刊介绍： This journal aims to review the most important, recently published research in psychiatry. By providing clear, insightful, balanced contributions by international experts, the journal intends to serve all those involved in the care of those affected by psychiatric disorders. We accomplish this aim by appointing international authorities to serve as Section Editors in key subject areas, such as anxiety, medicopsychiatric disorders, and schizophrenia and other related psychotic disorders. Section Editors, in turn, select topics for which leading experts contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, highlighted by annotated reference lists. An international Editorial Board reviews the annual table of contents, suggests articles of special interest to their country/region, and ensures that topics are current and include emerging research. Commentaries from well-known figures in the field are also provided.