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Sex Differences in Schizophrenia Across the Reproductive Lifespan. 精神分裂症在生殖寿命中的性别差异。
IF 6.7 2区 医学 Q1 PSYCHIATRY Pub Date : 2026-01-13 DOI: 10.1007/s11920-025-01659-9
Alexandre González-Rodríguez, Mentxu Natividad, Lorena Marín, María Emilia Chávez, Ariadna Balagué, Jennipher Paola Paolini San Miguel, José Antonio Monreal

Purpose of review: A number of sex differences have been reported in people with schizophrenia in terms of epidemiological data and clinical and social needs.

Recent findings: This review examines recent evidence on sex differences in clinical outcomes, medical comorbidities and social risk factors in schizophrenia. Sex-specific personality traits and the effects of childhood maltreatment are relevant in schizophrenia. Insomnia is more common in women and is associated with depressive symptoms and cognitive impairment. Differences in antipsychotic dose requirements, risk of hospitalization and adverse events between men and women with schizophrenia have been reported and vary with age. The association between negative symptoms and 10-year cardiovascular risk are more common in men. Hyperglycaemia and dyslipidaemia are potential targets for sex stratification in the treatment of schizophrenia. Living without a spouse is associated with an increased risk of schizophrenia, which is higher in men than in women. Loneliness and social isolation are positively associated with clinical symptoms in men. The mental, physical and social needs of men and women with schizophrenia differ. This should be recognised when planning sex-specific programmes for psychosis.

综述目的:在流行病学数据、临床和社会需求方面,已经报道了精神分裂症患者的一些性别差异。最新发现:本综述研究了精神分裂症临床结果、医学合并症和社会危险因素的性别差异的最新证据。性别特异性人格特征和童年虐待的影响与精神分裂症有关。失眠在女性中更为常见,并与抑郁症状和认知障碍有关。据报道,精神分裂症男女患者在抗精神病药物剂量要求、住院风险和不良事件方面存在差异,且随年龄而异。阴性症状与10年心血管风险之间的关联在男性中更为常见。高血糖和血脂异常是精神分裂症治疗中性别分层的潜在目标。没有配偶的生活与患精神分裂症的风险增加有关,男性患精神分裂症的风险高于女性。孤独和社会孤立与男性的临床症状呈正相关。精神分裂症患者的心理、生理和社会需求不同。在规划针对不同性别的精神病规划时,应认识到这一点。
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引用次数: 0
Eating Disorders and Subthreshold Symptoms in Pregnancy and the Postpartum Period: an Overview of Recent Research and Future Directions for Researchers and Clinicians. 妊娠和产后进食障碍和阈下症状:研究人员和临床医生的最新研究综述和未来方向。
IF 6.7 2区 医学 Q1 PSYCHIATRY Pub Date : 2026-01-08 DOI: 10.1007/s11920-025-01660-2
Christine C Call, Riley J Jouppi, Abigale L Regal, Caroline Christian, Lydia B Brown, Shannon D Donofry, Rachel P K Conlon, Michele D Levine

Purpose: Eating disorders and subthreshold symptoms during pregnancy and postpartum pose significant risks for maternal and child health. This review synthesizes recent findings (2020-2025) on epidemiology, assessment, and intervention to inform clinical care and research.

Recent findings: Eating disorders affect approximately 4% of pregnant individuals and over 9% of postpartum individuals. Subthreshold symptoms, particularly loss of control eating, are highly prevalent across both periods. Risk factors include maladaptive attitudes and worries related to pregnancy and motherhood and body comparison. Assessment tools adapted for pregnancy show promise, but no validated postpartum measures exist. Intervention research is sparse; two ongoing trials-an acceptance-based food craving intervention to reduce loss of control eating and an adapted Body Project to improve body image and prevent disordered eating-illustrate efforts to tailor evidence-based approaches for pregnancy. Pregnancy and postpartum present opportunities for prevention and treatment of eating disorders, but additional research is needed.

目的:孕期和产后饮食失调和阈下症状对母婴健康构成重大风险。本综述综合了流行病学、评估和干预方面的最新发现(2020-2025),为临床护理和研究提供信息。最近的研究发现:饮食失调影响了大约4%的孕妇和超过9%的产后个体。阈下症状,特别是饮食失控,在这两个时期都非常普遍。风险因素包括与怀孕、母性和身体比较有关的不适应态度和担忧。适用于妊娠的评估工具显示出希望,但没有有效的产后措施存在。干预研究较少;两项正在进行的试验——一项基于接受的食物渴望干预,旨在减少饮食失控;另一项改进的身体项目,旨在改善身体形象,防止饮食失调——说明了为怀孕量身定制循证方法的努力。怀孕和产后为预防和治疗饮食失调提供了机会,但还需要进一步的研究。
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引用次数: 0
The Use of Artificial Intelligence for Personalized Treatment in Psychiatry. 人工智能在精神病学个性化治疗中的应用。
IF 6.7 2区 医学 Q1 PSYCHIATRY Pub Date : 2025-12-29 DOI: 10.1007/s11920-025-01656-y
Sara Jalali, Qiong You, Victoria Xu, Langfan Chen, Jonathan Zini, Tihare Zamorano, Yangyu Luo, Timothy Friesen, Gabriel James Fontana, David Benrimoh

Purpose of review: This review examines the role of artificial intelligence (AI) in psychiatry in the past 5 years across four domains: screening; outcome prediction; risk and relapse prediction; and psychotherapy.

Recent findings: Machine learning models applied to questionnaires, electronic health records, neuroimaging, and digital phenotyping data demonstrate promising results for predicting symptom trajectories, relapse risk and treatment response, but external and clinical validation is rare. Randomized controlled trials provide some evidence for AI-enabled clinical decision support, but only preliminary evidence for chatbot-delivered psychotherapy. Some preliminary evidence for chatbots in screening exists. Ethical risks, including automation bias, model opacity and socioemotional harms, complicate integration into practice. Current evidence only supports AI's role as a complement to clinical expertise. To realize safe integration of AI into clinical practice, future work should focus on prospective, multi-site trials with active comparators, external validation across diverse populations, transparent reporting, and governance frameworks that prioritize explainability, oversight, and equity.

综述目的:本综述探讨了过去5年人工智能(AI)在精神病学中的作用,涉及四个领域:筛查;结果预测;风险及复发预测;和心理疗法。最近的发现:应用于问卷调查、电子健康记录、神经成像和数字表型数据的机器学习模型在预测症状轨迹、复发风险和治疗反应方面显示出有希望的结果,但外部和临床验证很少。随机对照试验为人工智能的临床决策支持提供了一些证据,但仅为聊天机器人提供的心理治疗提供了初步证据。一些初步证据表明,聊天机器人在筛选中是存在的。伦理风险,包括自动化偏见、模型不透明和社会情感伤害,使整合实践复杂化。目前的证据只支持人工智能作为临床专业知识的补充。为了实现人工智能与临床实践的安全整合,未来的工作应侧重于前瞻性、多地点试验、主动比较、跨不同人群的外部验证、透明报告和优先考虑可解释性、监督和公平性的治理框架。
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引用次数: 0
Staying Relevant in the Digital Age: Exploring the Evolving Frontier of Telehealth for Mental Health in the Military Health System and Veterans Health Administration. 在数字时代保持相关性:探索军事卫生系统和退伍军人健康管理中心理健康远程医疗的不断发展的前沿。
IF 6.7 2区 医学 Q1 PSYCHIATRY Pub Date : 2025-12-29 DOI: 10.1007/s11920-025-01651-3
Elizabeth A Greene, Eric J Serpico, Gary L Legault, Scott G Williams

Purpose of review: This review examines recent evidence for the effectiveness of telehealth in treating Post-Traumatic Stress Disorder (PTSD), Major Depressive Disorder (MDD), alcohol use disorder, and insomnia in military veterans and active-duty service members (ADSMs).

Recent findings: Recent randomized controlled trials and prospective cohort studies provide strong evidence that synchronous video-teleconference based therapy is effective for PTSD, MDD, and insomnia in this population. There is growing evidence for the effectiveness of internet-based self-guided therapy, particularly when combined with coaching support provided by telemedicine, for symptoms of PTSD, MDD, and insomnia. The effectiveness of telehealth in the treatment of alcohol use disorders is less well-supported, as is the effectiveness of mobile applications. These findings are supported by the team's analysis of the literature as well as an analysis provided by an Artificial Intelligence (AI) platform. The current evidence supports the use of synchronous video-teleconference and internet-based self-guided therapy with coaching support in the treatment of several common diagnoses in the military veteran and ADSM populations. Other modalities of telehealth require further research.

Human and animal rights: This article does not contain any studies with human or animal subjects performed by any of the authors.

综述目的:本综述探讨了远程医疗在治疗退伍军人和现役军人(ADSMs)创伤后应激障碍(PTSD)、重度抑郁症(MDD)、酒精使用障碍和失眠方面的有效性的最新证据。最近的发现:最近的随机对照试验和前瞻性队列研究提供了强有力的证据,表明同步视频电话会议治疗对这一人群的创伤后应激障碍、重度抑郁症和失眠有效。越来越多的证据表明,基于互联网的自我指导治疗,特别是与远程医疗提供的指导支持相结合,对创伤后应激障碍、重度抑郁症和失眠的症状是有效的。远程保健在治疗酒精使用障碍方面的有效性得到的支持较少,移动应用程序的有效性也是如此。这些发现得到了该团队对文献的分析以及人工智能(AI)平台提供的分析的支持。目前的证据支持在治疗退伍军人和ADSM人群的几种常见诊断中使用同步视频电话会议和基于互联网的辅导支持的自我指导治疗。远程保健的其他方式需要进一步研究。人权和动物权利:本文不包含任何作者对人类或动物受试者进行的任何研究。
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引用次数: 0
Recent Innovations in Eating Disorder Prevention and Early Intervention. 饮食失调预防和早期干预的最新创新。
IF 6.7 2区 医学 Q1 PSYCHIATRY Pub Date : 2025-12-26 DOI: 10.1007/s11920-025-01657-x
Kennedi Burton, Jennifer Finkelstein, Tiffany A Brown

Purpose of review: The purpose of this review is to synthesize recent advancements over the last four years in eating disorder prevention and early intervention research.

Recent findings: Our comprehensive review identified over 140 prevention and early intervention articles published from 2021 to 2024, with themes focused on specific intervention strategies or targets (e.g., dissonance, mindfulness, weight stigma), targeted populations (e.g., adolescents/school-based programs, athletes), digital-based interventions, system-level interventions, and early interventions. The eating disorder prevention and early intervention literature has expanded over the last several years. Based on the current state of the evidence, we outline future directions to help inform the field and continue movement towards accessible and inclusive eating disorder prevention.

综述目的:本综述的目的是综合近四年来饮食失调预防和早期干预研究的最新进展。最近的发现:我们的综合审查确定了从2021年到2024年发表的140多篇预防和早期干预文章,主题集中在特定的干预策略或目标(例如,失调、正念、体重耻辱感)、目标人群(例如,青少年/学校项目、运动员)、基于数字的干预、系统级干预和早期干预。在过去的几年里,饮食失调的预防和早期干预文献得到了扩展。根据目前的证据状况,我们概述了未来的方向,以帮助告知该领域,并继续朝着可获得和包容性饮食失调预防的方向发展。
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引用次数: 0
A Critical Review of Post-Childbirth Pain Experiences and Management in Relation to Postpartum Depression Risk for Racial and Ethnic Minorities. 少数民族与产后抑郁风险相关的分娩后疼痛经历及处理综述
IF 6.7 2区 医学 Q1 PSYCHIATRY Pub Date : 2025-12-22 DOI: 10.1007/s11920-025-01655-z
Sandraluz Lara-Cinisomo, Sudhamshi Beeram, Melany E Romero

Purpose: This critical review examines literature published between January 2020 and January 2025, focusing on overlapping pain-related factors during and after childbirth (e.g., pain experiences and management). These factors may increase vulnerability to postpartum depression, especially among racial and ethnic minorities.

Recent findings: The findings from the 23 studies reviewed indicate that several factors contribute to peripartum pain experienced by individuals giving birth. Factors influencing the birthing person's pain experiences include their mental health during pregnancy (such as depression and anxiety), delivery method (especially cesarean), pain management practices, discrimination toward racial and ethnic minorities, and overall neglect of pain. Additionally, healthcare providers' beliefs about pain management play a role in postpartum pain experiences. Individuals with a history of depression or anxiety often experience more severe postpartum pain. Mode of delivery is an important factor, as cesarean deliveries are associated with more severe pain than vaginal deliveries. However, intrapartum experiences and pain management significantly influence pain ratings. Analgesics during and after labor may buffer postpartum pain, but not always. Additionally, pain relief medications for patients with opioid use disorders can impact postpartum pain management. While healthcare providers rely on clinical assessments and patient-centered approaches to inform postpartum pain management, data from racial and ethnic minorities revealed that healthcare professionals often fail to recognize these patients' pain. This underscores the disparities in perspectives and experiences among patients. Post-childbirth pain experiences and their management strategies may increase the risk of postpartum depression, highlighting the necessity for researchers and practitioners to consider them.

目的:本综述回顾了2020年1月至2025年1月间发表的文献,重点关注分娩期间和分娩后疼痛相关的重叠因素(如疼痛经历和管理)。这些因素可能会增加产后抑郁症的易感性,特别是在少数种族和民族中。最近的发现:从23项研究的结果回顾表明,几个因素有助于围产期疼痛经历的个体分娩。影响分娩者疼痛经历的因素包括她们在怀孕期间的心理健康(如抑郁和焦虑)、分娩方法(尤其是剖宫产)、疼痛管理做法、对种族和少数民族的歧视以及对疼痛的整体忽视。此外,医疗保健提供者对疼痛管理的信念在产后疼痛体验中发挥作用。有抑郁或焦虑病史的人通常会经历更严重的产后疼痛。分娩方式是一个重要因素,因为剖宫产比阴道分娩有更严重的疼痛。然而,分娩经验和疼痛管理显著影响疼痛评分。分娩时和分娩后的镇痛药可以缓解产后疼痛,但并非总是如此。此外,阿片类药物使用障碍患者的止痛药会影响产后疼痛管理。虽然医疗保健提供者依靠临床评估和以患者为中心的方法来告知产后疼痛管理,但来自种族和少数民族的数据显示,医疗保健专业人员往往无法认识到这些患者的疼痛。这强调了患者在观点和经验上的差异。产后疼痛经历及其管理策略可能会增加产后抑郁症的风险,这突出了研究人员和从业人员考虑这些问题的必要性。
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引用次数: 0
Prevalence of Self-Reported Diagnoses of Attention-Deficit/Hyperactivity Disorder (ADHD) among Post-secondary Students in the U.S.: A Narrative Review. 美国中学生自我报告诊断为注意缺陷/多动障碍(ADHD)的患病率:一项叙述性回顾。
IF 6.7 2区 医学 Q1 PSYCHIATRY Pub Date : 2025-12-13 DOI: 10.1007/s11920-025-01653-1
Yaejin Cha, Justin J Choi, James Aluri

Purpose of review: To investigate the prevalence of self-reported diagnoses of ADHD among U.S. post-secondary students.

Recent findings: We identified fifteen empirical studies published in academic journals between 2008 and 2023 that reported ADHD prevalence estimates. These studies had variability in samples and methods and produced a wide range of prevalence estimates-3.4% to 11.2%-and an overall prevalence estimate of 9.1%. We supplemented the academic literature with data from two multi-institutional, annual surveys-the Healthy Minds Study and National College Health Assessment (NCHA III/IIIb). Their prevalence estimates for the 2024-2025 academic year were 14% and 15%, respectively, which reflected significant increases from their 2019-2020 estimates of 4% and 8%. Estimates for the prevalence of ADHD diagnoses vary by data source and method. Multi-institutional, annual surveys suggest an increase in prevalence in recent years. These data might warrant the strengthening of ADHD services provided by campus clinics.

回顾的目的:调查自我报告的ADHD诊断在美国大专学生中的流行程度。最近的发现:我们确定了2008年至2023年间发表在学术期刊上的15项实证研究,这些研究报告了ADHD的患病率估计。这些研究在样本和方法上存在差异,并产生了广泛的患病率估计值(3.4%至11.2%)和9.1%的总体患病率估计值。我们用两项多机构年度调查——健康心理研究和国家大学生健康评估(NCHA III/IIIb)的数据补充了学术文献。他们对2024-2025学年的患病率估计分别为14%和15%,与2019-2020学年的4%和8%的估计相比有显著增长。对ADHD诊断的患病率的估计因数据来源和方法而异。多机构的年度调查显示,近年来发病率有所上升。这些数据可能需要加强校园诊所提供的ADHD服务。
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引用次数: 0
Children's Coping in Disasters: Developments, Challenges, and Future Directions. 儿童在灾难中的应对:发展、挑战和未来方向。
IF 6.7 2区 医学 Q1 PSYCHIATRY Pub Date : 2025-12-08 DOI: 10.1007/s11920-025-01654-0
Tara Powell, Flora Cohen, Maegan Ramchal

Purpose of review: We review the published literature on children's coping in disasters, focusing on disaster type, cultural and socio-demographic influences, and the methods used to assess coping.

Recent findings: Disasters affect children and youth in diverse ways, shaped by both disaster type and broader contextual factors. Research has grown considerably over the past two decades, offering insights into adaptive and maladaptive coping in disaster contexts. However, the field remains constrained by several limitations: a lack of consensus on how coping is conceptualized in children, limited standardized measures specific to disaster contexts, and few culturally adapted tools that capture diverse coping processes across settings. A deeper understanding of children's disaster coping can be achieved by addressing gaps in definitions and tools through clearer conceptualization, culturally grounded measures, and longitudinal, multi-systems approaches. Addressing these gaps will help strengthen supports for children facing the increasing frequency and severity of disasters.

回顾目的:我们回顾了已发表的关于儿童应对灾害的文献,重点关注灾害类型、文化和社会人口影响,以及评估应对的方法。最近的发现:灾害以多种方式影响儿童和青年,受到灾害类型和更广泛的环境因素的影响。在过去的二十年里,研究有了长足的发展,对灾害背景下的适应性和非适应性应对提供了深入的见解。然而,该领域仍然受到一些限制的制约:缺乏关于如何在儿童中概念化应对的共识,针对灾害环境的标准化措施有限,以及很少有文化适应工具可以捕捉不同环境下的不同应对过程。通过更清晰的概念、基于文化的措施和纵向的多系统方法,解决定义和工具方面的差距,可以加深对儿童灾害应对的理解。解决这些差距将有助于加强对面临日益频繁和严重灾害的儿童的支持。
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引用次数: 0
Changes in Child and Youth Mental Health Following the Return To In-Person Learning Post-COVID-19 Pandemic. covid -19大流行后回归面对面学习后儿童和青少年心理健康的变化
IF 6.7 2区 医学 Q1 PSYCHIATRY Pub Date : 2025-12-01 Epub Date: 2025-10-07 DOI: 10.1007/s11920-025-01642-4
Erika Felix, Jennifer Greif Green

Purpose of review: Changes in youth mental health during the pandemic have been well documented globally, but research on how mental health changed when schools returned to in-person learning is just emerging. This review summarizes the available global research on child and youth mental health following school reopening for in-person learning.

Recent findings: Results varied by the mental health indicator being assessed and by subgroups of children and youth, with age-related differences, and possible gender-related influences. Some modifiable risk and protective factors examined included time spent on homework; internet and social media use; physical activity; communication/conflict with others; optimism; social relationships with family, teacher and peers; parental mental health; and inconsistent discipline. Some youth fared better when schools reopened in-person, but for others mental health challenges persisted. Mental health services shifted during the height of the pandemic, and some supports are no longer available. Continued monitoring is needed to help with recovery and resilience.

审查目的:在全球范围内,大流行期间青少年心理健康的变化已得到充分记录,但关于学校恢复面对面学习后心理健康如何变化的研究才刚刚出现。本文综述了学校重新开放面对面学习后儿童和青少年心理健康的现有全球研究。最近的发现:结果因评估的心理健康指标和儿童和青年亚组而异,存在年龄相关差异,并可能存在性别相关影响。一些可改变的风险和保护因素包括花在家庭作业上的时间;互联网和社交媒体的使用;身体活动;与他人的沟通/冲突;乐观;与家庭、老师和同龄人的社会关系;父母心理健康;以及不一致的纪律。当学校重新开放时,一些年轻人的情况有所好转,但对其他人来说,心理健康问题仍然存在。在疫情最严重的时候,精神卫生服务发生了变化,一些支持不再提供。需要继续监测,以帮助恢复和恢复。
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引用次数: 0
The Dynamics of Mood in Bipolar Disorder: How Mathematical Models Help Phenotype Individuals, Forecast Mood, and Clarify Underlying Mechanisms. 双相情感障碍的情绪动态:数学模型如何帮助表现型个体,预测情绪,并阐明潜在机制。
IF 6.7 2区 医学 Q1 PSYCHIATRY Pub Date : 2025-12-01 Epub Date: 2025-10-27 DOI: 10.1007/s11920-025-01647-z
Amy L Cochran, Jimmy Vineyard

Purpose of review: Mood in bipolar disorder (BP) fluctuates in complex and unpredictable ways that resist simple explanation. To capture this complexity, researchers have turned to modeling mood dynamics. This review organizes the recent literature around three key questions: How can modeling help phenotype BP? Can models accurately predict future mood? And can modeling clarify mechanisms underlying mood instability?

Recent findings: Models of mood dynamics carry clinically relevant information beyond standard measures, differentiating BP from other disorders and reflecting treatment response and impairment. Yet their ability to forecast mood tends to deteriorate within days, raising the possibility that fleeting predictability may be intrinsic to BP, not simply a technical limitation. Mood also appears to be best represented by two or more continuous latent dimensions, with states like mania and depression appearing as loosely defined regions. However, how mood unfolds over time remains poorly understood, particularly the relative influence of internal dynamics versus external triggers. Looking ahead, two priorities stand out: applying these models in real time to support clinical and research decisions, and validating them systematically through standardized forecasting tasks and shared longitudinal datasets integrating mood and physiological data. Together, these steps can help turn modeling into a practical tool for understanding and managing mood in BP.

综述目的:双相情感障碍(BP)的情绪波动方式复杂且不可预测,难以简单解释。为了捕捉这种复杂性,研究人员转向建立情绪动力学模型。这篇综述围绕三个关键问题组织了最近的文献:建模如何帮助BP表型?模型能准确预测未来的情绪吗?建模能阐明情绪不稳定的潜在机制吗?最近的研究发现:情绪动力学模型携带的临床相关信息超出标准测量,可将BP与其他疾病区分开来,并反映治疗反应和损害。然而,他们预测情绪的能力往往在几天内就会恶化,这增加了一种可能性,即短暂的可预测性可能是BP固有的,而不仅仅是一种技术限制。情绪似乎最好由两个或多个连续的潜在维度来代表,像躁狂和抑郁这样的状态出现在松散定义的区域。然而,情绪如何随着时间的推移而发展,尤其是内部动力与外部触发因素的相对影响,仍然知之甚少。展望未来,有两个重点突出:实时应用这些模型来支持临床和研究决策,以及通过标准化预测任务和整合情绪和生理数据的共享纵向数据集系统地验证这些模型。总之,这些步骤可以帮助将建模转变为理解和管理BP情绪的实用工具。
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引用次数: 0
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