{"title":"Cytotoxic iridoid glycosides from the aerial parts of <i>Paederia yunnanensis</i>.","authors":"Jiang Hu, Gui-Hua Yu, Feng-Ming Xu, Tao Lv, Qiang Li, Jing-Yi Zhang","doi":"10.1080/10286020.2025.2467321","DOIUrl":null,"url":null,"abstract":"<p><p>Three previously undescribed iridoid glycosides, 6<i>α-O</i>-<i>trans</i>-sinapoyl-paederosidic acid ethyl ester (<b>1</b>), 6'-<i>O</i>-<i>trans</i>-feruloyl-paederosidic acid methyl ester (<b>2</b>), and 10-<i>O</i>-<i>trans</i>-<i>p</i>-coumaroyl-(4<i>S</i>,6<i>R</i>)-3,4-dihydro-3<i>β</i>-ethoxypaederoside (<b>3</b>), were isolated from the 90% EtOH extract of the aerial parts of <i>Paederia yunnanensis</i>. The structures of the new compounds were elucidated by spectral methods such as 1D and 2D (<sup>1</sup>H-<sup>1</sup>H COSY, HMQC, and HMBC) NMR spectrometry, HR-ESI-MS, as well as ECD data. The isolated compounds were tested <i>in vitro</i> for cytotoxic activity against five tumor cell lines. These results revealed that <b>3</b> exhibited some cytotoxicities against all the tested tumor cell lines with IC<sub>50</sub> value less than 20.0 μM and provided a scientific basis for further processing and utilization of <i>P. yunnanensis</i>.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1112-1119"},"PeriodicalIF":1.3000,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Asian Natural Products Research","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1080/10286020.2025.2467321","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/2/21 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"CHEMISTRY, APPLIED","Score":null,"Total":0}
引用次数: 0
Abstract
Three previously undescribed iridoid glycosides, 6α-O-trans-sinapoyl-paederosidic acid ethyl ester (1), 6'-O-trans-feruloyl-paederosidic acid methyl ester (2), and 10-O-trans-p-coumaroyl-(4S,6R)-3,4-dihydro-3β-ethoxypaederoside (3), were isolated from the 90% EtOH extract of the aerial parts of Paederia yunnanensis. The structures of the new compounds were elucidated by spectral methods such as 1D and 2D (1H-1H COSY, HMQC, and HMBC) NMR spectrometry, HR-ESI-MS, as well as ECD data. The isolated compounds were tested in vitro for cytotoxic activity against five tumor cell lines. These results revealed that 3 exhibited some cytotoxicities against all the tested tumor cell lines with IC50 value less than 20.0 μM and provided a scientific basis for further processing and utilization of P. yunnanensis.
期刊介绍：
The Journal of Asian Natural Products Research (JANPR) publishes chemical and pharmaceutical studies in the English language in the field of natural product research on Asian ethnic medicine. The journal publishes work from scientists in Asian countries, e.g. China, Japan, Korea and India, including contributions from other countries concerning natural products of Asia. The journal is chemistry-orientated. Major fields covered are: isolation and structural elucidation of natural constituents (including those for non-medical uses), synthesis and transformation (including biosynthesis and biotransformation) of natural products, pharmacognosy, and allied topics. Biological evaluation of crude extracts are acceptable only as supporting data for pure isolates with well-characterized structures.
All published research articles in this journal have undergone rigorous peer review, based on initial editor screening and anonymized refereeing by at least two expert referees.
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