Emulgel-Based Formulations of Clobetasol Propionate: Formulation Development, Characterization, and Pharmacological Evaluation.

Q2 Pharmacology, Toxicology and Pharmaceutics Pharmaceutical nanotechnology Pub Date : 2025-02-20 DOI:10.2174/0122117385327270241224080729

Kuldeep Singh, Jeetendra Kumar Gupta, Divya Jain, Mukesh Chandra Sharma, Shivendra Kumar, Ramkumar Chaudhary, Sakshi Mishra

{"title":"Emulgel-Based Formulations of Clobetasol Propionate: Formulation Development, Characterization, and Pharmacological Evaluation.","authors":"Kuldeep Singh, Jeetendra Kumar Gupta, Divya Jain, Mukesh Chandra Sharma, Shivendra Kumar, Ramkumar Chaudhary, Sakshi Mishra","doi":"10.2174/0122117385327270241224080729","DOIUrl":null,"url":null,"abstract":"<p><p>Topical formulations of corticosteroids, particularly clobetasol propionate (CP), are commonly used to treat a range of dermatological conditions. CP is a potent corticosteroid known for its efficacy in managing inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses. Emulgel-based formulations of CP have emerged as an innovative approach, offering advantages like improved drug solubility, enhanced skin penetration, and extended drug release. This review aims to provide an updated overview of the latest advancements in the development and evaluation of CP emulgel formulations. Key aspects discussed include the selection and optimization of emulgel components, formulation characterization, in vitro drug release, and pharmacological activities such as anti-inflammatory and anti-pruritic effects. Emphasis is placed on recent studies and innovations that underscore the potential of CP emulgels in dermatological therapy, highlighting their promising applications in enhancing therapeutic efficacy and patient outcomes.</p>","PeriodicalId":19774,"journal":{"name":"Pharmaceutical nanotechnology","volume":" ","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Pharmaceutical nanotechnology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2174/0122117385327270241224080729","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"Pharmacology, Toxicology and Pharmaceutics","Score":null,"Total":0}

引用次数: 0

Abstract

Topical formulations of corticosteroids, particularly clobetasol propionate (CP), are commonly used to treat a range of dermatological conditions. CP is a potent corticosteroid known for its efficacy in managing inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses. Emulgel-based formulations of CP have emerged as an innovative approach, offering advantages like improved drug solubility, enhanced skin penetration, and extended drug release. This review aims to provide an updated overview of the latest advancements in the development and evaluation of CP emulgel formulations. Key aspects discussed include the selection and optimization of emulgel components, formulation characterization, in vitro drug release, and pharmacological activities such as anti-inflammatory and anti-pruritic effects. Emphasis is placed on recent studies and innovations that underscore the potential of CP emulgels in dermatological therapy, highlighting their promising applications in enhancing therapeutic efficacy and patient outcomes.

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

求助全文

约1分钟内获得全文去求助

来源期刊

Pharmaceutical nanotechnology Pharmacology, Toxicology and Pharmaceutics-Pharmaceutical Science

CiteScore

4.20

自引率

0.00%

发文量

期刊介绍： Pharmaceutical Nanotechnology publishes original manuscripts, full-length/mini reviews, thematic issues, rapid technical notes and commentaries that provide insights into the synthesis, characterisation and pharmaceutical (or diagnostic) application of materials at the nanoscale. The nanoscale is defined as a size range of below 1 µm. Scientific findings related to micro and macro systems with functionality residing within features defined at the nanoscale are also within the scope of the journal. Manuscripts detailing the synthesis, exhaustive characterisation, biological evaluation, clinical testing and/ or toxicological assessment of nanomaterials are of particular interest to the journal’s readership. Articles should be self contained, centred around a well founded hypothesis and should aim to showcase the pharmaceutical/ diagnostic implications of the nanotechnology approach. Manuscripts should aim, wherever possible, to demonstrate the in vivo impact of any nanotechnological intervention. As reducing a material to the nanoscale is capable of fundamentally altering the material’s properties, the journal’s readership is particularly interested in new characterisation techniques and the advanced properties that originate from this size reduction. Both bottom up and top down approaches to the realisation of nanomaterials lie within the scope of the journal.