Cancer and Accelerated Aging Research at the National Institutes of Health, 2013–2023: A Grant Portfolio Analysis

IF 4.5 2区医学 Q1 GERIATRICS & GERONTOLOGY Journal of the American Geriatrics Society Pub Date : 2025-02-21 DOI:10.1111/jgs.19414

Lisa Gallicchio, Rachelle Brick, Gina Tesauro, Lindsey Page, Paige Green, Jennifer L. Guida

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Abstract

Background

The purpose of this study was to describe the characteristics of the NIH-funded grant portfolio focused on cancer and accelerated aging.

Methods

Research project grants focused on cancer survivors and aging trajectories that were newly funded during fiscal years 2013 through 2023 were identified by first using a text mining algorithm from the NIH Research, Condition, and Disease Categorization (RCDC) system with cancer survivorship-relevant terms and then a list of aging-related terms that included aging, neurocognition, and physical function. Included grants were double coded to extract study characteristics.

Results

A total of 166 grants were identified, with the National Cancer Institute (NCI) and National Institute on Aging (NIA) funding 62.0% and 23.5% of the grants, respectively. The number of newly funded grants rose from nine in 2013 to 27 in 2023. Overall, the majority were observational studies (65.1%); 45% included study samples of multiple cancer types. The most commonly examined outcomes were cognitive (54.4%) or physical (37.5%) functioning; 30% of grants incorporated an aging-related biomarker. Few grants focused on racial and ethnic minority (3.0%) or rural cancer survivors (2.4%).

Conclusions

This portfolio analysis showed an increase in the number of NIH-funded grants focused on cancer survivors and accelerated aging, but notable gaps are evident. Given the rapidly growing survivor population, many of whom will experience accelerated aging trajectories, there is a critical need to better understand accelerated aging phenotypes and mechanisms, so that those at the highest risk for adverse aging-related effects can be identified and interventions developed.

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美国国立卫生研究院癌症和加速衰老研究，2013-2023：资助组合分析。

背景：本研究的目的是描述美国国立卫生研究院（NIH）资助的以癌症和加速衰老为重点的基金组合的特点：本研究旨在描述美国国立卫生研究院（NIH）资助的以癌症和加速衰老为重点的赠款组合的特点：方法：首先使用美国国立卫生研究院研究、条件和疾病分类（RCDC）系统中与癌症幸存者相关术语的文本挖掘算法，然后使用包括衰老、神经认知和身体功能在内的衰老相关术语列表，确定了2013至2023财年期间新资助的关注癌症幸存者和衰老轨迹的研究项目基金。对纳入的研究基金进行双重编码，以提取研究特征：结果：共确定了 166 项基金，其中由美国国立癌症研究所（NCI）和美国国立老龄化研究所（NIA）资助的基金分别占 62.0% 和 23.5%。新资助的基金数量从 2013 年的 9 项增加到 2023 年的 27 项。总体而言，大多数研究为观察性研究（65.1%）；45%的研究包括多种癌症类型的研究样本。最常见的研究结果是认知功能（54.4%）或身体功能（37.5%）；30%的研究基金纳入了与衰老相关的生物标志物。关注少数民族（3.0%）或农村癌症幸存者（2.4%）的资助很少：这项研究组合分析显示，由美国国立卫生研究院（NIH）资助的、关注癌症幸存者和加速衰老的基金数量有所增加，但差距也很明显。鉴于幸存者人数迅速增加，其中许多人将经历加速衰老的轨迹，因此亟需更好地了解加速衰老的表型和机制，以便确定那些与衰老相关的不良影响风险最高的人群并制定干预措施。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of the American Geriatrics Society 医学-老年医学

CiteScore

10.00

自引率

6.30%

发文量

504

审稿时长

3-6 weeks

期刊介绍： Journal of the American Geriatrics Society (JAGS) is the go-to journal for clinical aging research. We provide a diverse, interprofessional community of healthcare professionals with the latest insights on geriatrics education, clinical practice, and public policy—all supporting the high-quality, person-centered care essential to our well-being as we age. Since the publication of our first edition in 1953, JAGS has remained one of the oldest and most impactful journals dedicated exclusively to gerontology and geriatrics.