Association between platelet/high-density lipoprotein cholesterol ratio and blood eosinophil counts in American adults with asthma: a population-based study.

IF 3.9 2区 医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Lipids in Health and Disease Pub Date : 2025-02-21 DOI:10.1186/s12944-025-02479-9
Qian Zhao, Peng Yang, Jing-Pan Li, Lei Du, Wei Wang, Si-Xuan Zhu, Shan Wu, Yun-Feng Chen
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Abstract

Objective: This study aims to evaluate the relationship between the platelet-to-high-density lipoprotein cholesterol ratio (PHR) and blood eosinophil counts (BEOC) in asthmatic patients, using data from the National Health and Nutrition Examination Survey (NHANES) from 2011 to 2018.

Methods: This research explored the link between PHR and BEOC among adults with asthma, drawing on data from a representative U.S. population sample (n = 3034; NHANES 2011-2018). To assess this relationship, multivariable linear models were employed, alongside subgroup and interaction analyses to identify any potential variations across different groups. Additionally, generalized additive models, smooth curve fitting, and threshold effect analysis were employed to explore the relationships in greater detail. Sensitivity tests were performed to ensure the robustness of the findings.

Results: The weighted multivariable linear regression analysis showed that after adjusting for all covariables, each one-unit rise in PHR was linked to an increase of 41.61 in BEOC (β: 41.61, 95% CI: 25.25-57.97). Subgroup analyses demonstrated consistency across various categories, reinforcing the significant positive association between PHR and BEOC. Interaction tests indicated that this positive association remained stable regardless of factors such as body mass index, smoking, hypertension, or diabetes, with all interaction P-values greater than 0.05. Additionally, the application of generalized additive models and two-piece linear regression models further confirmed the linear association between PHR and BEOC.

Conclusions: Our study indicates that a higher PHR may be associated with an increased risk of elevated BEOC in American adults with asthma. Thus, PHR might be considered a potential marker for predicting elevated BEOC levels in this population.

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来源期刊
Lipids in Health and Disease
Lipids in Health and Disease 生物-生化与分子生物学
CiteScore
7.70
自引率
2.20%
发文量
122
审稿时长
3-8 weeks
期刊介绍: Lipids in Health and Disease is an open access, peer-reviewed, journal that publishes articles on all aspects of lipids: their biochemistry, pharmacology, toxicology, role in health and disease, and the synthesis of new lipid compounds. Lipids in Health and Disease is aimed at all scientists, health professionals and physicians interested in the area of lipids. Lipids are defined here in their broadest sense, to include: cholesterol, essential fatty acids, saturated fatty acids, phospholipids, inositol lipids, second messenger lipids, enzymes and synthetic machinery that is involved in the metabolism of various lipids in the cells and tissues, and also various aspects of lipid transport, etc. In addition, the journal also publishes research that investigates and defines the role of lipids in various physiological processes, pathology and disease. In particular, the journal aims to bridge the gap between the bench and the clinic by publishing articles that are particularly relevant to human diseases and the role of lipids in the management of various diseases.
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