Neonatal pulmonary function tests in infants born to COVID-19 positive mothers

IF 2.4 3区医学 Q2 OBSTETRICS & GYNECOLOGY Journal of Perinatology Pub Date : 2025-02-21 DOI:10.1038/s41372-025-02237-w

Katy Ruch, Kelvin D. MacDonald, Kseniya Parkhotyuk, Diane Schilling, Mathew Olson, Shawn Mehess, Kristin Milner, Cindy T. McEvoy

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Abstract

To compare pulmonary function tests (PFTs), specifically passive respiratory system compliance (Crs), in infants of mothers positive for COVID-19 during pregnancy compared to PFTs from a historical cohort of matched, healthy reference infants. A prospective cohort study of infants born to COVID-19 positive mothers. Crs was measured with the single breath occlusion technique. Historical cohort data was obtained from a pre-COVID-19 data repository. Respiratory questionnaires were done at 1-year postnatal age. Twenty-four PFTs in the COVID-19 cohort were compared with PFTs from 24 reference subjects. Infants of the COVID-19 positive mothers had a Crs of 3.57 ml/cmH2O versus 3.76 mL/cmH2O in the reference group (p > 0.05). The remaining PFT outcomes were comparable between groups. The COVID-19 infants reported more allergic symptoms and conditions through 1-year. We found no difference in Crs in infants of mothers with COVID-19 during pregnancy compared to a historical pre-COVID reference cohort.

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COVID-19 阳性母亲所生婴儿的新生儿肺功能测试。

目的：比较COVID-19阳性母亲怀孕期间婴儿的肺功能测试（PFTs），特别是被动呼吸系统顺应性（Crs），与匹配的健康参考婴儿的历史队列的PFTs进行比较。研究设计：对COVID-19阳性母亲所生婴儿的前瞻性队列研究。采用单次呼吸闭塞法测定Crs。历史队列数据来自covid -19前的数据库。在出生后1岁时进行呼吸系统问卷调查。结果：将COVID-19队列中24例PFTs与24例参考受试者的PFTs进行比较。COVID-19阳性母亲的婴儿Crs为3.57 ml/cmH2O，而对照组为3.76 ml/cmH2O （p < 0.05）。其余PFT结果组间具有可比性。在1年的时间里，COVID-19婴儿报告了更多的过敏症状和状况。结论：我们发现怀孕期间感染COVID-19母亲的婴儿的Crs与历史上的COVID-19前参考队列相比没有差异。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Perinatology 医学-妇产科学

CiteScore

5.40

自引率

6.90%

发文量

284

审稿时长

3-8 weeks

期刊介绍： The Journal of Perinatology provides members of the perinatal/neonatal healthcare team with original information pertinent to improving maternal/fetal and neonatal care. We publish peer-reviewed clinical research articles, state-of-the art reviews, comments, quality improvement reports, and letters to the editor. Articles published in the Journal of Perinatology embrace the full scope of the specialty, including clinical, professional, political, administrative and educational aspects. The Journal also explores legal and ethical issues, neonatal technology and product development. The Journal’s audience includes all those that participate in perinatal/neonatal care, including, but not limited to neonatologists, perinatologists, perinatal epidemiologists, pediatricians and pediatric subspecialists, surgeons, neonatal and perinatal nurses, respiratory therapists, pharmacists, social workers, dieticians, speech and hearing experts, other allied health professionals, as well as subspecialists who participate in patient care including radiologists, laboratory medicine and pathologists.