Impacts of vaping and marijuana use on airway health as determined by exhaled breath condensate (EBC).

IF 5.8 2区医学 Q1 Medicine Respiratory Research Pub Date : 2025-02-21 DOI:10.1186/s12931-025-03147-3

Dante E Rojas, Mitchell M McCartney, Eva Borras, Tristan L Hicks, Tiffany T Lam, Nicholas J Kenyon, Cristina E Davis

{"title":"Impacts of vaping and marijuana use on airway health as determined by exhaled breath condensate (EBC).","authors":"Dante E Rojas, Mitchell M McCartney, Eva Borras, Tristan L Hicks, Tiffany T Lam, Nicholas J Kenyon, Cristina E Davis","doi":"10.1186/s12931-025-03147-3","DOIUrl":null,"url":null,"abstract":"<p><p>Across the United States, there is increased use of cannabis products and electronic delivery systems for cannabis products and nicotine, yet little is known about their impacts on lung health. We analyzed exhaled breath condensate of 254 participants who were non-users and users who used cannabis and tobacco products. The 132 participants reported using a product (\"users\") were distributed into cohorts of tobacco products and cannabis products, with some participants following into multiple cohorts. Targeted analysis of inflammatory oxylipins found up-regulation among persons using tobacco products, while cannabis users had concentrations closer to nonusers, and often down-regulated. Untargeted screening of 403 significant metabolites found tobacco users had similar breath profiles, and that cannabis users had a similar profile that was closer to the profile of nonusers. Metabolites were significantly higher in breath of people using combustion products (tobacco and cannabis) relative to nonusers, and significantly lower in e-device users (nicotine and THC). Our work demonstrates the relative impact of e-delivery systems and cannabis products compared to traditional cigarette smoking on lung metabolic profiles.</p>","PeriodicalId":49131,"journal":{"name":"Respiratory Research","volume":"26 1","pages":"63"},"PeriodicalIF":5.8000,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11846476/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Respiratory Research","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1186/s12931-025-03147-3","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"Medicine","Score":null,"Total":0}

引用次数: 0

Abstract

Across the United States, there is increased use of cannabis products and electronic delivery systems for cannabis products and nicotine, yet little is known about their impacts on lung health. We analyzed exhaled breath condensate of 254 participants who were non-users and users who used cannabis and tobacco products. The 132 participants reported using a product ("users") were distributed into cohorts of tobacco products and cannabis products, with some participants following into multiple cohorts. Targeted analysis of inflammatory oxylipins found up-regulation among persons using tobacco products, while cannabis users had concentrations closer to nonusers, and often down-regulated. Untargeted screening of 403 significant metabolites found tobacco users had similar breath profiles, and that cannabis users had a similar profile that was closer to the profile of nonusers. Metabolites were significantly higher in breath of people using combustion products (tobacco and cannabis) relative to nonusers, and significantly lower in e-device users (nicotine and THC). Our work demonstrates the relative impact of e-delivery systems and cannabis products compared to traditional cigarette smoking on lung metabolic profiles.

Abstract Image

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

通过呼气冷凝物（EBC）测定的吸电子烟和吸食大麻对气道健康的影响。

在美国各地，大麻产品和大麻产品和尼古丁的电子传输系统的使用有所增加，但对其对肺部健康的影响知之甚少。我们分析了254名参与者的呼出气体，他们既不吸食大麻，也吸食大麻和烟草产品。报告使用某种产品的132名参与者（“使用者”）被分配到烟草制品和大麻制品的队列中，一些参与者被分成多个队列。有针对性的分析发现，在使用烟草产品的人群中，炎症性氧化脂素的浓度升高，而大麻使用者的浓度更接近非使用者，而且往往下调。对403种重要代谢物的无目标筛查发现，烟草使用者有相似的呼吸特征，大麻使用者的相似特征更接近非使用者的特征。使用燃烧产物（烟草和大麻）的人呼吸中的代谢物明显高于不使用的人，而使用电子设备的人呼吸中的代谢物（尼古丁和四氢大麻酚）明显较低。我们的工作表明，与传统吸烟相比，电子输送系统和大麻产品对肺部代谢谱的相对影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

Respiratory Research RESPIRATORY SYSTEM-

CiteScore

9.70

自引率

1.70%

发文量

314

审稿时长

4-8 weeks

期刊介绍： Respiratory Research publishes high-quality clinical and basic research, review and commentary articles on all aspects of respiratory medicine and related diseases. As the leading fully open access journal in the field, Respiratory Research provides an essential resource for pulmonologists, allergists, immunologists and other physicians, researchers, healthcare workers and medical students with worldwide dissemination of articles resulting in high visibility and generating international discussion. Topics of specific interest include asthma, chronic obstructive pulmonary disease, cystic fibrosis, genetics, infectious diseases, interstitial lung diseases, lung development, lung tumors, occupational and environmental factors, pulmonary circulation, pulmonary pharmacology and therapeutics, respiratory immunology, respiratory physiology, and sleep-related respiratory problems.