{"title":"Healing wounds in diabetes: Exploring cutting-edge natural extracellular vesicle therapeutics","authors":"Mumtaj Bano Miya , Pankaj Chaturvedi , Vandana Pathak , Prakash Chandra Gupta , Anuradha Kalani","doi":"10.1016/j.obmed.2025.100597","DOIUrl":null,"url":null,"abstract":"<div><div>Managing diabetes-related foot ulcers is challenging due to their slow healing process, peripheral neuropathy, reduced blood flow and increased risk of infection. Exploring alternative approaches, such as medicinal plant-based therapies, could provide promising solutions for diabetic wound healing. The current review discusses the therapeutic potential of different extracellular vesicles for diabetic wound healing. A newly developed oxygenated nanotherapeutic, OXY-Exo<sup><em>Aloe</em></sup>, is further discussed, which is formulated by combining the medicinal potential of <em>Aloe barbadensis, Azadirachta indica, and Zingiber officinale.</em> The oxygenated nanotherapeutics could offer a multi-faceted approach to wound healing and may revolutionize advancements in nanotechnology and medicinal plant-based therapies for the treatment of diabetic foot ulcers in the future.</div></div>","PeriodicalId":37876,"journal":{"name":"Obesity Medicine","volume":"54 ","pages":"Article 100597"},"PeriodicalIF":0.0000,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Obesity Medicine","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S245184762500017X","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"Medicine","Score":null,"Total":0}
引用次数: 0
Abstract
Managing diabetes-related foot ulcers is challenging due to their slow healing process, peripheral neuropathy, reduced blood flow and increased risk of infection. Exploring alternative approaches, such as medicinal plant-based therapies, could provide promising solutions for diabetic wound healing. The current review discusses the therapeutic potential of different extracellular vesicles for diabetic wound healing. A newly developed oxygenated nanotherapeutic, OXY-ExoAloe, is further discussed, which is formulated by combining the medicinal potential of Aloe barbadensis, Azadirachta indica, and Zingiber officinale. The oxygenated nanotherapeutics could offer a multi-faceted approach to wound healing and may revolutionize advancements in nanotechnology and medicinal plant-based therapies for the treatment of diabetic foot ulcers in the future.
Obesity MedicineMedicine-Public Health, Environmental and Occupational Health
CiteScore
5.50
自引率
0.00%
发文量
74
审稿时长
40 days
期刊介绍：
The official journal of the Shanghai Diabetes Institute Obesity is a disease of increasing global prevalence with serious effects on both the individual and society. Obesity Medicine focusses on health and disease, relating to the very broad spectrum of research in and impacting on humans. It is an interdisciplinary journal that addresses mechanisms of disease, epidemiology and co-morbidities. Obesity Medicine encompasses medical, societal, socioeconomic as well as preventive aspects of obesity and is aimed at researchers, practitioners and educators alike.
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