{"title":"Hepatoprotective Biphenyl Derivatives from Cucumis bisexualis","authors":"Qinge Ma, Wenmin Liu, Zhipei Sang, Rongrui Wei","doi":"10.1007/s10600-025-04578-6","DOIUrl":null,"url":null,"abstract":"<p>A new tetraphenylene, named 6-(3′,4′-dihydroxy-5-methyl-[1,1′-biphenyl]-3-yl)-2,5-dihydroxybenzofuran-7-yl 2,4-dihydroxy-3-(3-methylbut-2-en-1-yl)benzoate (<b>1</b>), and seven known biphenyl derivatives (<b>2–8</b>) were isolated from <i>Cucumis bisexualis</i> for the first time. The structures of compounds <b>(1–8</b>) were determined by their spectral data and related references. Compounds (<b>1–8</b>) were evaluated for their hepatoprotective activities against D-galactosamine-induced toxicity in HL-7702 cells, with bicyclol as a positive control. As a result, compounds <b>1</b>, <b>2</b>, and <b>4</b> displayed moderate hepatoprotective activities.</p>","PeriodicalId":514,"journal":{"name":"Chemistry of Natural Compounds","volume":"61 1","pages":"75 - 79"},"PeriodicalIF":0.9000,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Chemistry of Natural Compounds","FirstCategoryId":"92","ListUrlMain":"https://link.springer.com/article/10.1007/s10600-025-04578-6","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"CHEMISTRY, MEDICINAL","Score":null,"Total":0}
引用次数: 0
Abstract
A new tetraphenylene, named 6-(3′,4′-dihydroxy-5-methyl-[1,1′-biphenyl]-3-yl)-2,5-dihydroxybenzofuran-7-yl 2,4-dihydroxy-3-(3-methylbut-2-en-1-yl)benzoate (1), and seven known biphenyl derivatives (2–8) were isolated from Cucumis bisexualis for the first time. The structures of compounds (1–8) were determined by their spectral data and related references. Compounds (1–8) were evaluated for their hepatoprotective activities against D-galactosamine-induced toxicity in HL-7702 cells, with bicyclol as a positive control. As a result, compounds 1, 2, and 4 displayed moderate hepatoprotective activities.
期刊介绍：
Chemistry of Natural Compounds publishes reviews and general articles about the structure of different classes of natural compounds, the chemical characteristics of botanical families, genus, and species, to establish the comparative laws and connection between physiological activity and the structure of substances.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
