Hepatoprotective Biphenyl Derivatives from Cucumis bisexualis

Abstract

A new tetraphenylene, named 6-(3′,4′-dihydroxy-5-methyl-[1,1′-biphenyl]-3-yl)-2,5-dihydroxybenzofuran-7-yl 2,4-dihydroxy-3-(3-methylbut-2-en-1-yl)benzoate (1), and seven known biphenyl derivatives (2–8) were isolated from Cucumis bisexualis for the first time. The structures of compounds (1–8) were determined by their spectral data and related references. Compounds (1–8) were evaluated for their hepatoprotective activities against D-galactosamine-induced toxicity in HL-7702 cells, with bicyclol as a positive control. As a result, compounds 1, 2, and 4 displayed moderate hepatoprotective activities.