Moderation of midlife cognitive activity on tau-related cognitive impairment

IF 11.1 1区医学 Q1 CLINICAL NEUROLOGY Alzheimer's & Dementia Pub Date : 2025-02-23 DOI:10.1002/alz.14606

Kang Ko, Dahyun Yi, Min Soo Byun, Joon Hyung Jung, Nayeong Kong, Gijung Jung, Hyejin Ahn, Yoon Young Chang, Musung Keum, Jun-Young Lee, Yun-Sang Lee, Yu Kyeong Kim, Dong Young Lee, for the KBASE Research Group

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Abstract

INTRODUCTION

We investigated the moderating effects of midlife and late-life cognitive activity (CA) on the relationship between tau pathology and both cognition and cognitive decline.

METHODS

Eighty-nine non-demented older adults from a Korean cohort underwent comprehensive evaluations, including CA assessments and tau neuroimaging at baseline, and Mini-Mental State Examination (MMSE) at baseline and the 2-year follow-up.

RESULTS

Greater midlife CA was associated with higher MMSE scores in a given amount of tau pathology, whereas higher levels of midlife CA were associated with faster tau-related decline in MMSE scores, particularly in individuals with mild cognitive impairment. Late-life CA did not exhibit any interaction with tau on either MMSE scores or their 2-year change.

DISCUSSION

Greater midlife CA is generally associated with better cognitive performance despite the presence of tau pathology. However, paradoxically, increased midlife CA appears to be linked to a more rapid tau-related cognitive decline in already cognitively impaired individuals.

Highlights

Greater midlife cognitive activity (CA) was generally associated with better cognitive performance in a given amount of tau pathology.
Paradoxically, higher levels of midlife CA were related to a more rapid tau-related cognitive decline in already cognitively impaired individuals.
Late-life CA did not exhibit any moderation effect on the association between tau and cognitive performance or decline.

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中年认知活动对tau相关认知障碍的调节作用

我们研究了中年和晚年认知活动（CA）对tau病理与认知和认知衰退之间关系的调节作用。方法来自韩国队列的89名非痴呆老年人接受了综合评估，包括基线时的CA评估和tau神经成像，基线时的迷你精神状态检查（MMSE）和2年随访。结果：在一定数量的tau病理学中，较高的中年CA与较高的MMSE评分相关，而较高水平的中年CA与MMSE评分的tau相关下降更快相关，特别是在轻度认知障碍的个体中。老年CA在MMSE评分或其2年变化中均未表现出与tau的任何相互作用。尽管存在tau病理，较大的中年CA通常与更好的认知表现相关。然而，矛盾的是，在已经认知受损的个体中，中年CA的增加似乎与更快的tau相关的认知衰退有关。在一定数量的tau病理中，更大的中年认知活动（CA）通常与更好的认知表现相关。矛盾的是，在已经认知受损的个体中，较高水平的中年CA与更快的tau相关的认知衰退有关。晚年CA对tau与认知能力或衰退之间的关联没有任何调节作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Alzheimer's & Dementia 医学-临床神经学

CiteScore

14.50

自引率

5.00%

发文量

299

审稿时长

3 months

期刊介绍： Alzheimer's & Dementia is a peer-reviewed journal that aims to bridge knowledge gaps in dementia research by covering the entire spectrum, from basic science to clinical trials to social and behavioral investigations. It provides a platform for rapid communication of new findings and ideas, optimal translation of research into practical applications, increasing knowledge across diverse disciplines for early detection, diagnosis, and intervention, and identifying promising new research directions. In July 2008, Alzheimer's & Dementia was accepted for indexing by MEDLINE, recognizing its scientific merit and contribution to Alzheimer's research.