{"title":"Synergistic Protection of Alpha-Glucosyl Hesperidin and Procyanidin Against Testicular Ischemia-Reperfusion Injury","authors":"Ehsan Zeynali, Ali Soleimanzadeh, Saeed Azizi","doi":"10.1155/jfbc/5634210","DOIUrl":null,"url":null,"abstract":"<div>\n <p>The present study was designed to examine the protective effects of alpha-glucosyl hesperidin (AGH) and procyanidin (PC) against testicular ischemia/reperfusion (I/R) injury, which is a severe medical condition. Seven groups of male rats were divided into control, torsion/detorsion (T/D), T/D+50 mg/kg PC, T/D+25 mg/kg AGH, T/D+50 mg/kg AGH, T/D+50 mg/kg PC+25 mg/kg AGH, and T/D+50 mg/kg PC+50 mg/kg AGH. The evaluation of testicular tissue, sperm quality, oxidative status, gene activity, and fertility levels after T/D was conducted using various tests. The results showed that sperm motility, viability, and plasma membrane functionality, as well as total antioxidant capacity (TAC), superoxide dismutase (SOD), catalase (CAT), and <i>Bcl-2</i> gene expression levels, all increased after treatment with AGH or PC and coadministration. Additionally, the levels of glutathione (GSH), malondialdehyde (MDA), <i>Bax,</i> and <i>caspase-3</i> gene expression and abnormal morphology and DNA damage decreased compared to the T/D group. The study found that AGH and PC had a more substantial synergistic effect when used together to improve reproductive health following T/D damage.</p>\n </div>","PeriodicalId":15802,"journal":{"name":"Journal of Food Biochemistry","volume":"2025 1","pages":""},"PeriodicalIF":4.2000,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/jfbc/5634210","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Food Biochemistry","FirstCategoryId":"97","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1155/jfbc/5634210","RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
The present study was designed to examine the protective effects of alpha-glucosyl hesperidin (AGH) and procyanidin (PC) against testicular ischemia/reperfusion (I/R) injury, which is a severe medical condition. Seven groups of male rats were divided into control, torsion/detorsion (T/D), T/D+50 mg/kg PC, T/D+25 mg/kg AGH, T/D+50 mg/kg AGH, T/D+50 mg/kg PC+25 mg/kg AGH, and T/D+50 mg/kg PC+50 mg/kg AGH. The evaluation of testicular tissue, sperm quality, oxidative status, gene activity, and fertility levels after T/D was conducted using various tests. The results showed that sperm motility, viability, and plasma membrane functionality, as well as total antioxidant capacity (TAC), superoxide dismutase (SOD), catalase (CAT), and Bcl-2 gene expression levels, all increased after treatment with AGH or PC and coadministration. Additionally, the levels of glutathione (GSH), malondialdehyde (MDA), Bax, and caspase-3 gene expression and abnormal morphology and DNA damage decreased compared to the T/D group. The study found that AGH and PC had a more substantial synergistic effect when used together to improve reproductive health following T/D damage.
期刊介绍：
The Journal of Food Biochemistry publishes fully peer-reviewed original research and review papers on the effects of handling, storage, and processing on the biochemical aspects of food tissues, systems, and bioactive compounds in the diet.
Researchers in food science, food technology, biochemistry, and nutrition, particularly based in academia and industry, will find much of great use and interest in the journal. Coverage includes:
-Biochemistry of postharvest/postmortem and processing problems
-Enzyme chemistry and technology
-Membrane biology and chemistry
-Cell biology
-Biophysics
-Genetic expression
-Pharmacological properties of food ingredients with an emphasis on the content of bioactive ingredients in foods
Examples of topics covered in recently-published papers on two topics of current wide interest, nutraceuticals/functional foods and postharvest/postmortem, include the following:
-Bioactive compounds found in foods, such as chocolate and herbs, as they affect serum cholesterol, diabetes, hypertension, and heart disease
-The mechanism of the ripening process in fruit
-The biogenesis of flavor precursors in meat
-How biochemical changes in farm-raised fish are affecting processing and edible quality
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