{"title":"Two undescribed benzofuran derivatives from <i>chaetomium elatum</i>.","authors":"Chen-Yi Yan, Feng Ju, Yu-Hui Chen, Yu-Ting Mu, Yun-Jie Hu, Da-Le Guo, Yun Deng, Qi-Xuan Kuang","doi":"10.1080/14786419.2025.2469306","DOIUrl":null,"url":null,"abstract":"<p><p>Two undescribed benzofuran derivatives (<b>1</b>-<b>2</b>) were isolated from <i>Chaetomium elatum</i> using silica gel, Sephadex LH-20 column chromatography, and preparative high-performance liquid chromatography (HPLC). The structures of compound <b>1-2</b> were characterised by HRESIMS, NMR, HMBC, NOESY spectral analyses, and ECD calculations. Compounds <b>1-2</b> demonstrated the ability to mitigate the inflammatory response triggered by lipopolysaccharide (LPS) in RAW264.7 macrophages, as evidenced by RT-PCR assay results showing suppression of key inflammatory factors at the concentration of 30 μM. These findings suggest that <b>1-2</b> possess promising anti-inflammatory properties.</p>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-5"},"PeriodicalIF":1.9000,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Natural Product Research","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1080/14786419.2025.2469306","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, APPLIED","Score":null,"Total":0}
引用次数: 0
Abstract
Two undescribed benzofuran derivatives (1-2) were isolated from Chaetomium elatum using silica gel, Sephadex LH-20 column chromatography, and preparative high-performance liquid chromatography (HPLC). The structures of compound 1-2 were characterised by HRESIMS, NMR, HMBC, NOESY spectral analyses, and ECD calculations. Compounds 1-2 demonstrated the ability to mitigate the inflammatory response triggered by lipopolysaccharide (LPS) in RAW264.7 macrophages, as evidenced by RT-PCR assay results showing suppression of key inflammatory factors at the concentration of 30 μM. These findings suggest that 1-2 possess promising anti-inflammatory properties.
期刊介绍：
The aim of Natural Product Research is to publish important contributions in the field of natural product chemistry. The journal covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds.
The communications include coverage of work on natural substances of land and sea and of plants, microbes and animals. Discussions of structure elucidation, synthesis and experimental biosynthesis of natural products as well as developments of methods in these areas are welcomed in the journal. Finally, research papers in fields on the chemistry-biology boundary, eg. fermentation chemistry, plant tissue culture investigations etc., are accepted into the journal.
Natural Product Research issues will be subtitled either ""Part A - Synthesis and Structure"" or ""Part B - Bioactive Natural Products"". for details on this , see the forthcoming articles section.
All manuscript submissions are subject to initial appraisal by the Editor, and, if found suitable for further consideration, to peer review by independent, anonymous expert referees. All peer review is single blind and submission is online via ScholarOne Manuscripts.
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