{"title":"Fatal case of Leptospira wolffii infection in Sikkim, India: An autochthonous case from a new geographical region","authors":"Shrijana Gurung , Dipesh Tewari , Urgen Sherpa , Tashi Pegey Chhophel , Aktarul Islam Siddique , Neelanjana Sarmah , Biswajyoti Borkakoty","doi":"10.1016/j.ijmmb.2025.100813","DOIUrl":null,"url":null,"abstract":"<div><div>This case report describes the first documented fatal case of <em>Leptospira wolffii</em> in Sikkim, India, marking a novel geographic occurrence of leptospirosis in the Himalayan state. A 40-year-old female presented with fever, sepsis, and acute kidney injury, succumbing despite intensive care and antibiotic treatment. Targeted 16S rRNA sequencing confirmed a 100 % identity with <em>L. wolffii</em>. Phylogenetic analysis showed close relatedness to strains from Thailand, Bangladesh, and Assam. Environmental investigations revealed rodent infestation and livestock proximity as potential sources. This study underscores the need for awareness of leptospirosis in non-endemic regions, rapid diagnostics, and a one health approach to mitigate such outbreaks.</div></div>","PeriodicalId":13284,"journal":{"name":"Indian Journal of Medical Microbiology","volume":"54 ","pages":"Article 100813"},"PeriodicalIF":1.4000,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Indian Journal of Medical Microbiology","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S025508572500026X","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"IMMUNOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
This case report describes the first documented fatal case of Leptospira wolffii in Sikkim, India, marking a novel geographic occurrence of leptospirosis in the Himalayan state. A 40-year-old female presented with fever, sepsis, and acute kidney injury, succumbing despite intensive care and antibiotic treatment. Targeted 16S rRNA sequencing confirmed a 100 % identity with L. wolffii. Phylogenetic analysis showed close relatedness to strains from Thailand, Bangladesh, and Assam. Environmental investigations revealed rodent infestation and livestock proximity as potential sources. This study underscores the need for awareness of leptospirosis in non-endemic regions, rapid diagnostics, and a one health approach to mitigate such outbreaks.
期刊介绍：
Manuscripts of high standard in the form of original research, multicentric studies, meta analysis, are accepted. Current reports can be submitted as brief communications. Case reports must include review of current literature, clinical details, outcome and follow up. Letters to the editor must be a comment on or pertain to a manuscript already published in the IJMM or in relation to preliminary communication of a larger study.
Review articles, Special Articles or Guest Editorials are accepted on invitation.
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