Effects of target coverage on local recurrence in stereotactic body radiotherapy for early-stage lung squamous cell carcinoma.

IF 2.1 4区医学 Japanese Journal of Radiology Pub Date : 2025-02-22 DOI:10.1007/s11604-025-01749-x

Shuou Sudo, Nozomi Kita, Natsuo Tomita, Taiki Takaoka, Dai Okazaki, Masanari Niwa, Akira Torii, Seiya Takano, Masanosuke Oguri, Akane Matsuura, Machiko Ukai, Akio Niimi, Akio Hiwatashi

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Abstract

Background and purpose: This study investigated effects of target coverage on local recurrence (LR) in stereotactic body radiotherapy (SBRT) for early-stage lung squamous cell carcinoma (SCC).

Materials and methods: Patients with clinical stage IA1-IIA lung SCC treated with SBRT were included in the analysis. Doses of 48-52 Gy were prescribed to the isocenter of the planning target volume according to the tumor diameter. The primary endpoint was LR. To examine the independent effects of dosimetric factors on LR after adjustment for clinical factors, Fine-Gray model with death as a competing risk was used for evaluation.

Results: Among all 59 patients analyzed, the median follow-up was 42 months. The 3-year LR rate was 24.0%. Univariate analysis of clinical factors showed that biologically effective dose calculated with an α/β value of 10 (BED₁₀) was associated with LR (p = 0.033). After adjustment for clinical factors, internal target volume (ITV) Dmean was associated with LR (p = 0.049). Subgroup analysis was performed for each prescribed dose group. The results of Fine-Gray model and receiver operating characteristic curve analysis showed that ITV Dmean > 100% of the prescribed dose was the best indicator of preventing LR.

Conclusions: ITV coverage may be particularly important in SBRT for early-stage lung SCC.

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来源期刊

Japanese Journal of Radiology Medicine-Radiology, Nuclear Medicine and Imaging

自引率

4.80%

发文量

133

期刊介绍： Japanese Journal of Radiology is a peer-reviewed journal, officially published by the Japan Radiological Society. The main purpose of the journal is to provide a forum for the publication of papers documenting recent advances and new developments in the field of radiology in medicine and biology. The scope of Japanese Journal of Radiology encompasses but is not restricted to diagnostic radiology, interventional radiology, radiation oncology, nuclear medicine, radiation physics, and radiation biology. Additionally, the journal covers technical and industrial innovations. The journal welcomes original articles, technical notes, review articles, pictorial essays and letters to the editor. The journal also provides announcements from the boards and the committees of the society. Membership in the Japan Radiological Society is not a prerequisite for submission. Contributions are welcomed from all parts of the world.