Trimester-specific reference intervals for blood lipid levels and their associations with adverse pregnancy outcomes in Southeast China.

IF 3.9 2区医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Lipids in Health and Disease Pub Date : 2025-02-22 DOI:10.1186/s12944-025-02494-w

Lili Yang, Zhaozhen Liu, Jiayi Chen, Chong Miao, Qingxiu Li, Jinying Chen, Wenjuan Liu, Haiyan Gao, Wei Li, Zhengqin Wu, Bin Sun, Yibing Zhu, Haibo Li

{"title":"Trimester-specific reference intervals for blood lipid levels and their associations with adverse pregnancy outcomes in Southeast China.","authors":"Lili Yang, Zhaozhen Liu, Jiayi Chen, Chong Miao, Qingxiu Li, Jinying Chen, Wenjuan Liu, Haiyan Gao, Wei Li, Zhengqin Wu, Bin Sun, Yibing Zhu, Haibo Li","doi":"10.1186/s12944-025-02494-w","DOIUrl":null,"url":null,"abstract":"Background: Trimester-specific reference intervals (TSRIs) for maternal lipid profiles should be determined, and the impact of dyslipidemia on adverse pregnancy outcomes (APOs) should be estimated.Methods: Data from 25,081 pregnant women in a large Southeast Chinese cohort were collected. Serial lipid profiling was performed throughout gestation, with measurements obtained during the first, second, and third trimesters, as well as within 24 h of delivery. The truncated maximum likelihood (TML) method, the Hoffman method, and inverse modelling were employed to establish TSRIs for lipids, with TML as the primary method. The associations of dyslipidemia with APOs were investigated by logistic regressions within the setting of TSRIs for various lipids.Results: The TSRIs established by the TML method were as follows: 3.36-6.06, 4.19-7.89, 4.60-8.97, and 4.41-8.79 mmol/L for total cholesterol; 0.66-2.32, 1.11-3.75, 1.49-4.77, and 1.61-6.14 mmol/L for triglycerides; 1.42-3.61, 1.94-5.13, 1.95-5.39, and 1.86-5.50 mmol/L for low-density lipoprotein cholesterol; 1.11-2.31, 1.30-2.75, 1.24-2.59, and 1.20-2.65 mmol/L for high-density lipoprotein cholesterol; 1.89-4.20, 2.59-5.85, 2.87-6.17, and 2.88-6.78 mmol/L for non-high-density lipoprotein cholesterol; 1.04-1.96, 1.25-2.41, 1.23-2.46, and 1.25-2.47 g/L for apolipoprotein A1; 0.43-0.82, 0.63-1.17, 0.65-1.55, and 0.79-1.77 g/L for apolipoprotein B; and 0.27-0.79, 0.35-0.94, 0.39-1.11, and 0.40-1.15 for the apolipoprotein B and apolipoprotein A1 ratio from the first trimester to the delivery period, respectively. The results of the Hoffman and inverse modelling methods closely aligned with those of the TML method. In pregnant women, lipid levels that deviate above or below the established TSRIs are significantly associated with the occurrence of APOs.Conclusion: TSRIs are recommended for the identification and management of dyslipidemia during pregnancy. Inappropriate maternal blood lipid levels are associated with an increased risk of APOs.","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":"24 1","pages":"68"},"PeriodicalIF":3.9000,"publicationDate":"2025-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11846285/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Lipids in Health and Disease","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1186/s12944-025-02494-w","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Background: Trimester-specific reference intervals (TSRIs) for maternal lipid profiles should be determined, and the impact of dyslipidemia on adverse pregnancy outcomes (APOs) should be estimated.

Methods: Data from 25,081 pregnant women in a large Southeast Chinese cohort were collected. Serial lipid profiling was performed throughout gestation, with measurements obtained during the first, second, and third trimesters, as well as within 24 h of delivery. The truncated maximum likelihood (TML) method, the Hoffman method, and inverse modelling were employed to establish TSRIs for lipids, with TML as the primary method. The associations of dyslipidemia with APOs were investigated by logistic regressions within the setting of TSRIs for various lipids.

Results: The TSRIs established by the TML method were as follows: 3.36-6.06, 4.19-7.89, 4.60-8.97, and 4.41-8.79 mmol/L for total cholesterol; 0.66-2.32, 1.11-3.75, 1.49-4.77, and 1.61-6.14 mmol/L for triglycerides; 1.42-3.61, 1.94-5.13, 1.95-5.39, and 1.86-5.50 mmol/L for low-density lipoprotein cholesterol; 1.11-2.31, 1.30-2.75, 1.24-2.59, and 1.20-2.65 mmol/L for high-density lipoprotein cholesterol; 1.89-4.20, 2.59-5.85, 2.87-6.17, and 2.88-6.78 mmol/L for non-high-density lipoprotein cholesterol; 1.04-1.96, 1.25-2.41, 1.23-2.46, and 1.25-2.47 g/L for apolipoprotein A1; 0.43-0.82, 0.63-1.17, 0.65-1.55, and 0.79-1.77 g/L for apolipoprotein B; and 0.27-0.79, 0.35-0.94, 0.39-1.11, and 0.40-1.15 for the apolipoprotein B and apolipoprotein A1 ratio from the first trimester to the delivery period, respectively. The results of the Hoffman and inverse modelling methods closely aligned with those of the TML method. In pregnant women, lipid levels that deviate above or below the established TSRIs are significantly associated with the occurrence of APOs.

Conclusion: TSRIs are recommended for the identification and management of dyslipidemia during pregnancy. Inappropriate maternal blood lipid levels are associated with an increased risk of APOs.

Abstract Image

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

中国东南地区孕妇血脂水平的孕期特异性参考区间及其与不良妊娠结局的关系

背景：应确定母体脂质谱的妊娠期特异性参考区间（TSRIs），并评估血脂异常对不良妊娠结局（APOs）的影响。方法：收集来自中国东南部大型队列的25,081名孕妇的数据。在整个妊娠期间进行一系列脂质分析，在第一，第二和第三个三个月以及分娩后24小时内进行测量。以截断最大似然法（TML）、Hoffman法和逆建模法为主要方法，建立脂类TSRIs。血脂异常与apo的关系通过logistic回归在各种脂类的TSRIs设置中进行了研究。结果：TML法建立的总胆固醇TSRIs分别为：3.36 ~ 6.06、4.19 ~ 7.89、4.60 ~ 8.97、4.41 ~ 8.79 mmol/L；甘油三酯为0.66-2.32、1.11-3.75、1.49-4.77和1.61-6.14 mmol/L；低密度脂蛋白胆固醇分别为1.42 ~ 3.61、1.94 ~ 5.13、1.95 ~ 5.39、1.86 ~ 5.50 mmol/L；高密度脂蛋白胆固醇为1.11-2.31、1.30-2.75、1.24-2.59、1.20-2.65 mmol/L；非高密度脂蛋白胆固醇为1.89 ~ 4.20、2.59 ~ 5.85、2.87 ~ 6.17、2.88 ~ 6.78 mmol/L；载脂蛋白A1为1.04-1.96、1.25-2.41、1.23-2.46、1.25-2.47 g/L；载脂蛋白B为0.43 ~ 0.82、0.63 ~ 1.17、0.65 ~ 1.55、0.79 ~ 1.77 g/L；孕早期至分娩期间载脂蛋白B和载脂蛋白A1的比值分别为0.27 ~ 0.79、0.35 ~ 0.94、0.39 ~ 1.11和0.40 ~ 1.15。Hoffman和逆建模方法的结果与TML方法的结果密切一致。在孕妇中，脂质水平高于或低于既定的TSRIs与apo的发生显著相关。结论：TSRIs可用于妊娠期血脂异常的识别和治疗。不适当的母亲血脂水平与apo的风险增加有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

Lipids in Health and Disease 生物-生化与分子生物学

CiteScore

7.70

自引率

2.20%

发文量

122

审稿时长

3-8 weeks

期刊介绍： Lipids in Health and Disease is an open access, peer-reviewed, journal that publishes articles on all aspects of lipids: their biochemistry, pharmacology, toxicology, role in health and disease, and the synthesis of new lipid compounds. Lipids in Health and Disease is aimed at all scientists, health professionals and physicians interested in the area of lipids. Lipids are defined here in their broadest sense, to include: cholesterol, essential fatty acids, saturated fatty acids, phospholipids, inositol lipids, second messenger lipids, enzymes and synthetic machinery that is involved in the metabolism of various lipids in the cells and tissues, and also various aspects of lipid transport, etc. In addition, the journal also publishes research that investigates and defines the role of lipids in various physiological processes, pathology and disease. In particular, the journal aims to bridge the gap between the bench and the clinic by publishing articles that are particularly relevant to human diseases and the role of lipids in the management of various diseases.