Effect of adaptive variable-resistance training on chemotherapy-induced sarcopenia, fatigue, and functional restriction in pediatric survivors of acute lymphoblastic leukemia: a prospective randomized controlled trial.
Ragab K Elnaggar, Waleed S Mahmoud, Mohamed S Abdrabo, Mahmoud S Elfakharany
{"title":"Effect of adaptive variable-resistance training on chemotherapy-induced sarcopenia, fatigue, and functional restriction in pediatric survivors of acute lymphoblastic leukemia: a prospective randomized controlled trial.","authors":"Ragab K Elnaggar, Waleed S Mahmoud, Mohamed S Abdrabo, Mahmoud S Elfakharany","doi":"10.1007/s00520-025-09250-x","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose: </strong>With the rising survival rate among children and adolescents with acute lymphoblastic leukemia (ALL), prioritizing patient-centered care to address the long-term effects of chemotherapy through tailored rehabilitation interventions is essential for optimizing their quality of life. The purpose of this study was to investigate the impact of an 8-week intervention using adaptive variable-resistance training (Adaptive-VRT) on chemotherapy-induced sarcopenia, fatigue, and functional restrictions in pediatric survivors of ALL.</p><p><strong>Methods: </strong>A prospective randomized controlled trial included a total of 62 survivors of ALL, aged 12-18 years, and completed maintenance chemotherapy. Participants were randomized into two groups: the Adaptive-VRT group (n = 31), assigned the Adaptive-VRT intervention, and the control group (n = 31), which adhered to the standard exercise protocol. Baseline and post-intervention measurements were undertaken to analyze sarcopenia-related variables (i.e., muscle thickness and muscle strength), fatigue, and functional performance.</p><p><strong>Results: </strong>The Adaptive-VRT group exhibited more favorable changes in muscle thickness [thigh thickness (P < .001; η<sup>2</sup><sub>P</sub> = 0.32); rectus femoris (P < .001; η<sup>2</sup><sub>P</sub> = 0.21); vastus intermedius (P = .002; η<sup>2</sup><sub>P</sub> = 0.15)], and peak concentric torque of quadriceps [at speed of 90°/s (P = .005; η<sup>2</sup><sub>P</sub> = 0.13), 120°/s (P = .021; η<sup>2</sup><sub>P</sub> = 0.10), or 180°/s (P = .008; η<sup>2</sup><sub>P</sub> = 0.11)] in comparison with the control group. Additionally, the Adaptive-VRT group reported lower fatigue levels (P = .031; η<sup>2</sup><sub>P</sub> = 0.08) and demonstrated better functional performance [6-min walk test (P < .001; η<sup>2</sup><sub>P</sub> = 0.25), 4 × 10-m shuttle running test (P < .001; η<sup>2</sup><sub>P</sub> = 0.24), as well as timed up and down stairs (P < .0006; η<sup>2</sup><sub>P</sub> = 0.18)].</p><p><strong>Conclusion: </strong>The findings suggest that Adaptive-VRT is a promising intervention for ameliorating chemotherapy-induced sarcopenia, fatigue, and functional limitations in pediatric ALL survivors.</p><p><strong>Trial registration: </strong>ClinicalTrials.gov Identifier: NCT06338020.</p>","PeriodicalId":22046,"journal":{"name":"Supportive Care in Cancer","volume":"33 3","pages":"214"},"PeriodicalIF":3.0000,"publicationDate":"2025-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Supportive Care in Cancer","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s00520-025-09250-x","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"HEALTH CARE SCIENCES & SERVICES","Score":null,"Total":0}
引用次数: 0
Abstract
Purpose: With the rising survival rate among children and adolescents with acute lymphoblastic leukemia (ALL), prioritizing patient-centered care to address the long-term effects of chemotherapy through tailored rehabilitation interventions is essential for optimizing their quality of life. The purpose of this study was to investigate the impact of an 8-week intervention using adaptive variable-resistance training (Adaptive-VRT) on chemotherapy-induced sarcopenia, fatigue, and functional restrictions in pediatric survivors of ALL.
Methods: A prospective randomized controlled trial included a total of 62 survivors of ALL, aged 12-18 years, and completed maintenance chemotherapy. Participants were randomized into two groups: the Adaptive-VRT group (n = 31), assigned the Adaptive-VRT intervention, and the control group (n = 31), which adhered to the standard exercise protocol. Baseline and post-intervention measurements were undertaken to analyze sarcopenia-related variables (i.e., muscle thickness and muscle strength), fatigue, and functional performance.
Results: The Adaptive-VRT group exhibited more favorable changes in muscle thickness [thigh thickness (P < .001; η2P = 0.32); rectus femoris (P < .001; η2P = 0.21); vastus intermedius (P = .002; η2P = 0.15)], and peak concentric torque of quadriceps [at speed of 90°/s (P = .005; η2P = 0.13), 120°/s (P = .021; η2P = 0.10), or 180°/s (P = .008; η2P = 0.11)] in comparison with the control group. Additionally, the Adaptive-VRT group reported lower fatigue levels (P = .031; η2P = 0.08) and demonstrated better functional performance [6-min walk test (P < .001; η2P = 0.25), 4 × 10-m shuttle running test (P < .001; η2P = 0.24), as well as timed up and down stairs (P < .0006; η2P = 0.18)].
Conclusion: The findings suggest that Adaptive-VRT is a promising intervention for ameliorating chemotherapy-induced sarcopenia, fatigue, and functional limitations in pediatric ALL survivors.
期刊介绍：
Supportive Care in Cancer provides members of the Multinational Association of Supportive Care in Cancer (MASCC) and all other interested individuals, groups and institutions with the most recent scientific and social information on all aspects of supportive care in cancer patients. It covers primarily medical, technical and surgical topics concerning supportive therapy and care which may supplement or substitute basic cancer treatment at all stages of the disease.
Nursing, rehabilitative, psychosocial and spiritual issues of support are also included.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
