Tetrasubstituted imidazole-based multifunctional fluorophores: trace water detection and lipid droplet (LD) imaging studies†

IF 4.2 2区 化学 Q2 CHEMISTRY, MULTIDISCIPLINARY Chemical Communications Pub Date : 2025-06-02 DOI:10.1039/d4cc06435f
Mohammad Masood Zafar , Rashmi Yadav , Alok Singh , Nidhi Tyagi , Animesh Samanta , Rakesh K. Mishra
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引用次数: 0

Abstract

Two tetrasubstituted imidazoles, denoted as and , with flexible and rigid cores, respectively, displayed remarkable photophysical properties as well as aggregation-induced emission. exhibited trace water detection in THF with an LOD of 0.03 wt%. Importantly, and both efficiently targeted lipid droplets (LDs) with high specificity in HeLa cells. These probes were further applied to monitor LD growth induced by oleic-acid–mediated lipid accumulation.
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基于四取代咪唑的多功能荧光团:痕量水检测和脂滴(ld)成像研究
四取代咪唑,tsm -1;TSIm-2分别具有柔性芯和刚性芯,表现出优异的光物理性能和聚集致发光性能。TSIm-1在THF中检测出痕量水,LOD为0.03 wt%。重要的是tsm -1 &;TSIm-2探针在HeLa细胞中具有高特异性,可有效靶向脂滴,并可进一步用于油酸介导的脂质积累诱导的脂滴生长。
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来源期刊
Chemical Communications
Chemical Communications 化学-化学综合
CiteScore
8.60
自引率
4.10%
发文量
2705
审稿时长
1.4 months
期刊介绍: ChemComm (Chemical Communications) is renowned as the fastest publisher of articles providing information on new avenues of research, drawn from all the world''s major areas of chemical research.
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