{"title":"“Repair and Fold” DNA Nanotweezers for Measuring DNA Alkylation Repair Mediated by ALKBH","authors":"Fengze Jiang, Cui Zhang, Xiangnan Wang, Yuan Yin, Jieling Hong, Hao Tang, Lijuan Tang, Zhenkun Wu","doi":"10.1039/d5an00099h","DOIUrl":null,"url":null,"abstract":"We reported a novel DNA lesion-modified nanotweezer that underwent conformational switch upon ALKBH enzymes-mediated lesion repair. We demonstrated that the DNA lesion-modified nanotweezer enabled specifically and rapidly monitoring ALKBH2 and ALKBH3 activities and screening inhibitors. Important, this strategy allowed evaluating ALKBH2-associated drug resistance in cells.","PeriodicalId":63,"journal":{"name":"Analyst","volume":"74 1","pages":""},"PeriodicalIF":3.6000,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Analyst","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1039/d5an00099h","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, ANALYTICAL","Score":null,"Total":0}
引用次数: 0
Abstract
We reported a novel DNA lesion-modified nanotweezer that underwent conformational switch upon ALKBH enzymes-mediated lesion repair. We demonstrated that the DNA lesion-modified nanotweezer enabled specifically and rapidly monitoring ALKBH2 and ALKBH3 activities and screening inhibitors. Important, this strategy allowed evaluating ALKBH2-associated drug resistance in cells.
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