Fengze Jiang, Cui Zhang, Xiangnan Wang, Yuan Yin, Jieling Hong, Hao Tang, Li-Juan Tang and Zhenkun Wu
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引用次数: 0
Abstract
We report a novel DNA lesion-modified nanotweezer that underwent conformational switching upon ALKBH enzyme-mediated lesion repair. We demonstrated that the DNA lesion-modified nanotweezer enabled specific and rapid monitoring of ALKBH2 and ALKBH3 activities and screening of inhibitors. Importantly, this strategy allowed evaluating ALKBH2-associated drug resistance in cells.
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