{"title":"Smart polymers advance analytical chemistry","authors":"Yahui Zhang , Xinjia Zhao , Guangyan Qing","doi":"10.1016/j.trac.2025.118198","DOIUrl":null,"url":null,"abstract":"<div><div>The “precision medicine” project put forward higher requirements for analytical chemistry, centering on new material development. Given the increasing diversity of complex samples and rising demands on analytical methods, breakthroughs in the creation of analytical materials that offer selectivity, sensitivity, speed, and specificity are required. As a star system in material science, smart polymers can respond to subtle changes in external stimuli, leading to significant conformational changes in their polymer chains, and further translating, transferring, and amplifying the stimulus signals into macroscopic properties of the material. Their excellent controllability and adjustability in both structures and functions inject fresh energy into the advancement of analytic methods. This review concisely presents the latest research regarding the advancements of smart polymers in analytical chemistry, and furthermore proposes the challenges and feasible solutions that smart polymers encounter during design and application. These materials will accelerate the arrival of a new era of precision medicine.</div></div>","PeriodicalId":439,"journal":{"name":"Trends in Analytical Chemistry","volume":"187 ","pages":"Article 118198"},"PeriodicalIF":12.0000,"publicationDate":"2025-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Trends in Analytical Chemistry","FirstCategoryId":"1","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0165993625000664","RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, ANALYTICAL","Score":null,"Total":0}
引用次数: 0
Abstract
The “precision medicine” project put forward higher requirements for analytical chemistry, centering on new material development. Given the increasing diversity of complex samples and rising demands on analytical methods, breakthroughs in the creation of analytical materials that offer selectivity, sensitivity, speed, and specificity are required. As a star system in material science, smart polymers can respond to subtle changes in external stimuli, leading to significant conformational changes in their polymer chains, and further translating, transferring, and amplifying the stimulus signals into macroscopic properties of the material. Their excellent controllability and adjustability in both structures and functions inject fresh energy into the advancement of analytic methods. This review concisely presents the latest research regarding the advancements of smart polymers in analytical chemistry, and furthermore proposes the challenges and feasible solutions that smart polymers encounter during design and application. These materials will accelerate the arrival of a new era of precision medicine.
期刊介绍：
TrAC publishes succinct and critical overviews of recent advancements in analytical chemistry, designed to assist analytical chemists and other users of analytical techniques. These reviews offer excellent, up-to-date, and timely coverage of various topics within analytical chemistry. Encompassing areas such as analytical instrumentation, biomedical analysis, biomolecular analysis, biosensors, chemical analysis, chemometrics, clinical chemistry, drug discovery, environmental analysis and monitoring, food analysis, forensic science, laboratory automation, materials science, metabolomics, pesticide-residue analysis, pharmaceutical analysis, proteomics, surface science, and water analysis and monitoring, these critical reviews provide comprehensive insights for practitioners in the field.
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