Optimizing Prussian blue synthesis: exploring the influence of synthesis parameters on maximum binding capacity of Prussian blue for thallium

Abstract

This study optimized Prussian Blue (PB) synthesis parameters to enhance its binding capacity for thallium (Tl(I)). Using direct (PB-1) and indirect (PB-2) methods, key parameters such as stirring time, drying conditions, oxidant concentration, and iron content were evaluated. For PB-1, the optimal conditions were 12-h stirring, 4-h drying at 60 °C, resulting in a maximum binding capacity (MBC) of 200 mg/g. For PB-2, the optimal parameters included 2-h drying at 80 °C, 20 mL oxidant, and 2-h aging at 60 °C, yielding an MBC of 208.33 mg/g. These findings ensure improved therapeutic efficacy of PB as an active pharmaceutical ingredient. Yes, the street name for the affiliation one is correct