From toasted skin to tumors: a retrospective nationwide case-control analysis investigating the link between erythema ab igne and various skin cancers.

Q3 Medicine Baylor University Medical Center Proceedings Pub Date : 2025-02-05 eCollection Date: 2025-01-01 DOI:10.1080/08998280.2025.2458993

Kritin K Verma, Maitreyi Dhavala, Jalyn Vo, Tejas P Joshi, Ida F Orengo, Michelle B Tarbox, Daniel P Friedmann, Zeena Y Nawas

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Abstract

This study investigated erythema ab igne (EAI) and comorbid skin cancers. Each EAI case, searched by ICD-10-CM code L59.0 in the All of Us database, was compared to four controls, matched by sex at birth, age, and self-identified race/ethnicity. Demographics and skin cancer comorbidities were assessed with odds ratios (ORs) and 95% confidence intervals (CIs) using Wald's method. EAI was most prevalent between 60 and 70 years of age. A female-to-male ratio of 1:1 was observed between ages 40 and 50. EAI patients had a statistically significant increased risk of basal cell carcinoma (OR, 10.67; 95% CI, 2.76-41.30; P < 0.001), squamous cell carcinoma (OR, 27.84; 95% CI, 1.42-545.59; P = 0.03), and melanoma (OR, 8.00; 95% CI, 1.43-44.60; P = 0.02). Additional tumors were analyzed, but insufficient case/control data was obtained from the database. In conclusion, EAI is positively correlated with skin cancers. Awareness and prevention of EAI is warranted.

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本研究调查了点状红斑（EAI）和合并皮肤癌的情况。根据我们所有人数据库中的 ICD-10-CM 代码 L59.0 搜索到的每个 EAI 病例都与四个对照组进行了比较，对照组的出生性别、年龄和自我认定的种族/人种相匹配。人口统计学和皮肤癌合并症的评估采用了沃尔德方法，得出了几率比（OR）和 95% 的置信区间（CI）。EAI在60至70岁之间最为普遍。在 40 至 50 岁之间，女性与男性的比例为 1:1。EAI患者罹患基底细胞癌（OR，10.67；95% CI，2.76-41.30；P = 0.03）和黑色素瘤（OR，8.00；95% CI，1.43-44.60；P = 0.02）的风险在统计学上显著增加。还对其他肿瘤进行了分析，但未能从数据库中获得足够的病例/对照数据。总之，EAI 与皮肤癌呈正相关。应提高对 EAI 的认识并加以预防。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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