{"title":"Bioactive steroids from marine-derived fungi: a review (2015-2023).","authors":"Xue-Yang Ma, Huan-Nan Wang, Li-Xiang Sun, Jin Sun, Shi-Hao Jin, Fang-Xu Dai, Chun-Mei Sai, Zhen Zhang","doi":"10.1080/10286020.2025.2464690","DOIUrl":null,"url":null,"abstract":"<p><p>Marine fungi, rich in unique secondary metabolites with diverse activities, are a valuable source for novel lead compounds. Steroids, a prominent class of bioactive compounds from marine fungi, have been extensively studied for their diverse pharmacological properties. This review describes the structural diversity, bioactivities, and sources of 175 marine fungal steroids (2015-2023), mainly from <i>Aspergillus</i>, <i>Penicillium</i>, <i>Talaromyces</i>, etc., in seaweed, mangroves, sediments, and marine animals like sponges and corals. Among them, 74 steroids exhibit antibacterial, antitumor, enzyme inhibitory, antiviral, and other activities, providing valuable leads for steroid drug development and advancing marine pharmaceutical research.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-27"},"PeriodicalIF":1.3000,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Asian Natural Products Research","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1080/10286020.2025.2464690","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, APPLIED","Score":null,"Total":0}
引用次数: 0
Abstract
Marine fungi, rich in unique secondary metabolites with diverse activities, are a valuable source for novel lead compounds. Steroids, a prominent class of bioactive compounds from marine fungi, have been extensively studied for their diverse pharmacological properties. This review describes the structural diversity, bioactivities, and sources of 175 marine fungal steroids (2015-2023), mainly from Aspergillus, Penicillium, Talaromyces, etc., in seaweed, mangroves, sediments, and marine animals like sponges and corals. Among them, 74 steroids exhibit antibacterial, antitumor, enzyme inhibitory, antiviral, and other activities, providing valuable leads for steroid drug development and advancing marine pharmaceutical research.
期刊介绍：
The Journal of Asian Natural Products Research (JANPR) publishes chemical and pharmaceutical studies in the English language in the field of natural product research on Asian ethnic medicine. The journal publishes work from scientists in Asian countries, e.g. China, Japan, Korea and India, including contributions from other countries concerning natural products of Asia. The journal is chemistry-orientated. Major fields covered are: isolation and structural elucidation of natural constituents (including those for non-medical uses), synthesis and transformation (including biosynthesis and biotransformation) of natural products, pharmacognosy, and allied topics. Biological evaluation of crude extracts are acceptable only as supporting data for pure isolates with well-characterized structures.
All published research articles in this journal have undergone rigorous peer review, based on initial editor screening and anonymized refereeing by at least two expert referees.
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