Eriodictyol inhibits the proliferation and inflammatory response in keratinocytes in psoriasis through inactivating DYRK1A-mediated endoplasmic reticulum stress
Rui Yuan , Qi-Chao Sun , Yue-Peng An , Qing Zhang , Qiong Zhang , Yue Li
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Abstract
Our work is conducted to reveal the impacts of eriodictyol on psoriasis. CCK-8 and EdU assays measured HaCaT cell proliferation. ELISA detected the activities of inflammatory cytokines and chemokines. Western blot examined the expressions of proliferation-, inflammation- and ERS-associated proteins. Molecular docking predicted the binding affinity of eriodictyol to DYRK1A. RT-qPCR and Western blot analyzed DYRK1A expression. Eriodictyol inhibited the proliferation and inflammatory response in M5-challenged HaCaT cells. Eriodictyol targeted and down-regulated DYRK1A expression. DYRK1A overexpression abolished the impacts of eriodictyol on M5-stimulated HaCaT cells. Conclusively, eriodictyol might suppress ERS mediated by DYRK1A to elicit anti-psoriasis functions.
期刊介绍：
The Journal of Asian Natural Products Research (JANPR) publishes chemical and pharmaceutical studies in the English language in the field of natural product research on Asian ethnic medicine. The journal publishes work from scientists in Asian countries, e.g. China, Japan, Korea and India, including contributions from other countries concerning natural products of Asia. The journal is chemistry-orientated. Major fields covered are: isolation and structural elucidation of natural constituents (including those for non-medical uses), synthesis and transformation (including biosynthesis and biotransformation) of natural products, pharmacognosy, and allied topics. Biological evaluation of crude extracts are acceptable only as supporting data for pure isolates with well-characterized structures.
All published research articles in this journal have undergone rigorous peer review, based on initial editor screening and anonymized refereeing by at least two expert referees.
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