Relationship between life’s essential 8, vitamin D, and cardiometabolic outcomes

Abstract

Aims

To assess the association between cardiovascular health (CVH) and cardiometabolic outcomes and the impact of vitamin D on the relationship. Additionally, we seek to analyze the predictive ability of CVH metrics for cardiometabolic outcomes.

Methods

This cross-sectional study included 21,913 adult participants of the National Health and Nutrition Examination Survey (2007–2018). Logistic regression models and restricted cubic spline curves were employed to evaluate the association between CVH and cardiometabolic outcomes and analyze the influence of vitamin D on the relationship. Receiver operating characteristic curves were used to assess the predictive ability of CVH metrics for cardiometabolic outcomes.

Results

The study included 21,913 participants, among whom 6193 (28.3%) were classified as having low CVH, 14,080 (64.3%) as having moderate CVH, and 1640 (7.5%) as having high CVH. CVH scores were significantly negatively correlated with cardiometabolic outcomes. Among the CVH metrics, blood glucose and blood pressure had higher predictive values for cardiovascular disease, chronic kidney disease, hypertension, and diabetes. Additionally, there was a significant interaction between CVH and vitamin D.

Conclusion

These findings underscore that higher CVH scores, assessed by Life’s Essential 8, are associated with lower risks of cardiometabolic outcomes. Improving CVH contributes to reducing the burden of disease and promoting human health.