Informatividad a posteriori en casos de paternidad estándar con el kit Investigator Argus X-12 y hallazgos mutacionales

Eduardo Rojas-Prado, Irán Cortés-Trujillo, Mayra E. García-Aceves, Mariana Chávez-Arreguín, Karina González-Becerra, Alma F. Favela-Mendoza, Héctor Rangel-Villalobos
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引用次数: 0

Abstract

Introduction

The Investigator Argus X-12 kit is a valuable complementary tool for human identification purposes, especially for solving complex kinship cases. The analysis of these cases generates valuable information in routine forensic work, such as a posteriori informativeness (LR: likelihood ratio) and mutation rates.

Objetive

To analyze the LR offered by the Argus X-12 QS kit in 74 Mexican families, including the father, mother, and daughter(s), respectively.

Methods

Exact LRs were estimated with the FamlinkX software in the families as paternity trio cases (n = 74; average 8.E + 14) and duo cases (n = 148; average 6.1E + 11), omitting the mother and father, respectively.

Results

The LR of the trios (a posteriori) was significantly higher than the (a priori) parameter IP typical (3.98E + 04). As reference, we report the LR of complex kinship cases solved with X-STRs: maternal half-sisters (LR = 111), paternal half-sisters (LR = 5567), paternal half-sisters with their mothers (LR = 6.0E + 07, and paternal grandmother-granddaughter (LR = 15,864). Nine mutations were detected in 161 meiosis. The mutation rate was estimated in seven X-STRs, which was 0,0062 (1/161) for DXS10148, DXS10135, DXS8378, DXS10146, and DXS7423, and 0,0124 (2/161) for DXS10074 and DXS10101. These findings will be useful in future meta-analyses to achieve more conclusive estimates. A null allele in DXS10148 was inferred between a mother and daughter, supported by the low probability that the finding is explained by an 8-step mutation (26.1  18), and the low frequency of the 26.1 homozygote.

Conclusion

The a posteriori informativeness of Argus X-12 in paternity and kinship cases described herein, justify the inclusion of the X-STRs in forensic genetics labs.
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使用 Investigator Argus X-12 套件和突变结果的标准亲子鉴定案例中的后验信息量
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来源期刊
Revista Espanola de Medicina Legal
Revista Espanola de Medicina Legal Medicine-Pathology and Forensic Medicine
CiteScore
1.90
自引率
0.00%
发文量
27
审稿时长
41 days
期刊最新文献
Nota del publisher Muertes en custodia: Un problema complejo Sumisión química. Evaluación del grado de conocimiento de los profesionales sanitarios Informatividad a posteriori en casos de paternidad estándar con el kit Investigator Argus X-12 y hallazgos mutacionales Muertes en prisión: hallazgos toxicológicos en los casos analizados en el Instituto Nacional de Toxicología y Ciencias Forenses (Madrid) en el período 2021–2023
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