Prevalence of depression in people with epilepsy: A hospital-based study in Cameroon

IF 2.3 3区医学 Q2 BEHAVIORAL SCIENCES Epilepsy & Behavior Pub Date : 2025-02-26 DOI:10.1016/j.yebeh.2025.110326

Daniel Gams Massi , Richy Feudjio , Christian Eyoum , Lionel Paternoster , Annick Mélanie Magnerou , Nadine Tavares Ferreira , Jose-Antonio Elosegi , Callixte Kuate Tegueu , Njankouo Yacouba Mapoure

{"title":"Prevalence of depression in people with epilepsy: A hospital-based study in Cameroon","authors":"Daniel Gams Massi , Richy Feudjio , Christian Eyoum , Lionel Paternoster , Annick Mélanie Magnerou , Nadine Tavares Ferreira , Jose-Antonio Elosegi , Callixte Kuate Tegueu , Njankouo Yacouba Mapoure","doi":"10.1016/j.yebeh.2025.110326","DOIUrl":null,"url":null,"abstract":"<div><h3>Introduction</h3><div>depression is a psychiatric disorder present in many chronic diseases with varying prevalences. In people with epilepsy (PWE), it represents the most frequent psychiatric comorbidity associated with impaired quality of life, and increased risk of suicide. The aim of this research was to determine the prevalence and factors associated with depression in PWE.</div></div><div><h3>Methods</h3><div>this was a cross-sectional study with an age- and sex- matched control group, conducted between February 12 and May 15, 2024, in two referral hospital of Douala. It included individuals (PWE and controls) aged 18 years and older who agreed to participate in the study. Individuals (PWE and controls) with a serious general health problem that could have a significant impact on mental status (hypertension, HIV, diabetes, renal failure, heart failure, dementia, bipolar disorder) or an inability to communicate were excluded. Recruitment was done through an online and in-person survey using a form. We collected sociodemographic data, and data on epilepsy in PWE. Depression was evaluated using the PHQ-9 scale. We used the Generalized Anxiety Disorder Questionnaire (GAD-7) to assess anxiety disorders. Univariate and multivariate analysis (binary logistic regression) were used to identify the factors significantly associated with depression in PWE. The significance threshold was considered for a value of p < 0.05.</div></div><div><h3>Results</h3><div>a total of 633 individuals, including 211 PWE, were included in the study. The prevalence of depression was significantly higher in PWE (24.6 %) compared to controls (11.8 %) (OR: 2.0, 95 %CI: 1.433–2.905, p < 0.001). Anxiety disorders was significantly higher in PWE (OR: 1.6, 95 %CI: 1.101–2.397, p = 0.014). Factors independently associated to depression were female sex (OR: 2.7, 95 %CI: 1.115–6.343, p = 0.027), suicidal ideation (OR: 5.8, 95 %CI: 2.083–16.174, p = 0.001), and anxiety disorders (OR: 10.2, 95 %CI: 4.023–25.748, p < 0.001).</div></div><div><h3>Conclusion</h3><div>the prevalence of depression is high in PWE compared to controls in Douala. A systematic screening should be included in the follow-up of PWE.</div></div>","PeriodicalId":11847,"journal":{"name":"Epilepsy & Behavior","volume":"165 ","pages":"Article 110326"},"PeriodicalIF":2.3000,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Epilepsy & Behavior","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1525505025000654","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"BEHAVIORAL SCIENCES","Score":null,"Total":0}

引用次数: 0

Abstract

Introduction

depression is a psychiatric disorder present in many chronic diseases with varying prevalences. In people with epilepsy (PWE), it represents the most frequent psychiatric comorbidity associated with impaired quality of life, and increased risk of suicide. The aim of this research was to determine the prevalence and factors associated with depression in PWE.

Methods

this was a cross-sectional study with an age- and sex- matched control group, conducted between February 12 and May 15, 2024, in two referral hospital of Douala. It included individuals (PWE and controls) aged 18 years and older who agreed to participate in the study. Individuals (PWE and controls) with a serious general health problem that could have a significant impact on mental status (hypertension, HIV, diabetes, renal failure, heart failure, dementia, bipolar disorder) or an inability to communicate were excluded. Recruitment was done through an online and in-person survey using a form. We collected sociodemographic data, and data on epilepsy in PWE. Depression was evaluated using the PHQ-9 scale. We used the Generalized Anxiety Disorder Questionnaire (GAD-7) to assess anxiety disorders. Univariate and multivariate analysis (binary logistic regression) were used to identify the factors significantly associated with depression in PWE. The significance threshold was considered for a value of p < 0.05.

Results

a total of 633 individuals, including 211 PWE, were included in the study. The prevalence of depression was significantly higher in PWE (24.6 %) compared to controls (11.8 %) (OR: 2.0, 95 %CI: 1.433–2.905, p < 0.001). Anxiety disorders was significantly higher in PWE (OR: 1.6, 95 %CI: 1.101–2.397, p = 0.014). Factors independently associated to depression were female sex (OR: 2.7, 95 %CI: 1.115–6.343, p = 0.027), suicidal ideation (OR: 5.8, 95 %CI: 2.083–16.174, p = 0.001), and anxiety disorders (OR: 10.2, 95 %CI: 4.023–25.748, p < 0.001).

Conclusion

the prevalence of depression is high in PWE compared to controls in Douala. A systematic screening should be included in the follow-up of PWE.

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

癫痫患者抑郁患病率：喀麦隆一项基于医院的研究

抑郁症是一种精神障碍，存在于许多慢性疾病中，患病率各不相同。在癫痫患者（PWE）中，它是与生活质量受损和自杀风险增加相关的最常见精神共病。本研究的目的是确定PWE患者抑郁的患病率和相关因素。方法本研究为横断面研究，于2024年2月12日至5月15日在杜阿拉的两家转诊医院进行，对照组年龄和性别匹配。它包括18岁及以上同意参加研究的个人（PWE和对照组）。有可能对精神状态产生重大影响的严重一般健康问题（高血压、艾滋病毒、糖尿病、肾衰竭、心力衰竭、痴呆、双相情感障碍）或无法沟通的个体（PWE和对照组）被排除在外。招聘是通过使用表格的在线和面对面调查完成的。我们收集了社会人口统计数据，以及PWE患者的癫痫数据。抑郁症采用PHQ-9量表进行评估。我们使用广泛性焦虑障碍问卷（GAD-7）来评估焦虑障碍。采用单因素和多因素分析（二元logistic回归）确定与PWE患者抑郁显著相关的因素。显著性阈值为p <；0.05.结果共纳入633人，其中PWE 211人。PWE组抑郁症患病率（24.6%）明显高于对照组（11.8%）(OR: 2.0, 95% CI: 1.433-2.905, p <；0.001)。焦虑障碍显著高于PWE （OR: 1.6, 95% CI: 1.101 ~ 2.397, p = 0.014）。与抑郁独立相关的因素有女性（OR: 2.7, 95% CI: 1.115-6.343, p = 0.027）、自杀意念（OR: 5.8, 95% CI: 2.083-16.174, p = 0.001）和焦虑障碍(OR: 10.2, 95% CI: 4.023-25.748, p <；0.001)。结论杜阿拉市PWE患者抑郁症患病率高于对照组。PWE的随访应包括系统的筛查。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

Epilepsy & Behavior 医学-行为科学

CiteScore

5.40

自引率

15.40%

发文量

385

审稿时长

43 days

期刊介绍： Epilepsy & Behavior is the fastest-growing international journal uniquely devoted to the rapid dissemination of the most current information available on the behavioral aspects of seizures and epilepsy. Epilepsy & Behavior presents original peer-reviewed articles based on laboratory and clinical research. Topics are drawn from a variety of fields, including clinical neurology, neurosurgery, neuropsychiatry, neuropsychology, neurophysiology, neuropharmacology, and neuroimaging. From September 2012 Epilepsy & Behavior stopped accepting Case Reports for publication in the journal. From this date authors who submit to Epilepsy & Behavior will be offered a transfer or asked to resubmit their Case Reports to its new sister journal, Epilepsy & Behavior Case Reports.