Validity of dynamic optical breast imaging (DOBI) in diagnosis of malignant features of breast cancer

Abstract

Objective

To investigate the effectiveness of dynamic optical breast imaging technology (DOBI) in diagnosing malignant features of breast cancer.

Methods

213 patients with breast diseases underwent DOBI examination followed by ultrasound-guided hollow-core needle aspiration biopsy within one week. Diagnostic accuracy of DOBI for breast masses of different lesion sizes and breast cancers of different pathological types was analyzed.

Results

Pathological biopsy identified 20 malignant lesions and 193 benign lesions among the study participants. A total of 247 lesions were detected in benign cases, while 24 lesions were detected in malignant cases. The diagnostic accuracies of DOBI for breast masses with diameters ≤1 cm, 1–2 cm, and ≥2 cm were found to be 82.35%, 82.83%, and 87.60%, respectively. For invasive ductal carcinoma, ductal carcinoma in situ, and invasive lobular carcinoma, DOBI exhibited diagnostic accuracies of 53.85%, 60.00%, and 33.33%, respectively. Using breast puncture biopsy as gold standard, the sensitivity, specificity, misdiagnosis rate, missed diagnosis rate, and area under the curve of DOBI in diagnosing breast cancer were determined as 80.00%, 84.21%, 15.03%, 20.00%, and 0.862 (95% CI: 0.613–0.978), respectively.

Conclusion

DOBI holds promising application prospects in diagnosing malignant features of breast cancer, providing an effective basis for early diagnosis and treatment.