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Impact of case management on chemotherapy adherence, complications, and quality of life post-bladder tumor resection 病例管理对膀胱肿瘤切除术后化疗依从性、并发症和生活质量的影响
IF 2.5 4区 综合性期刊 Q2 MULTIDISCIPLINARY SCIENCES Pub Date : 2026-01-17 DOI: 10.1016/j.jrras.2026.102178
Qiumei Huang, Yudui Xia, Jingfen Cui, Xinli Wang

Purpose

Successful management of non-muscle-invasive bladder cancer (NMIBC) following transurethral resection of bladder tumor (TURBT) depends critically on compliance with intravesical chemotherapy. This study evaluates the impact of a case management model on patient adherence and prognosis.

Methods

This retrospective cohort analysis enrolled NMIBC patients who underwent intravesical chemotherapy after TURBT from June 2022 to June 2024. Subjects were allocated to either a case management cohort (n = 47) or a conventional care cohort (n = 43). Evaluations conducted at 6 and 12 months post-intervention encompassed adherence to therapy, scores from the Functional Assessment of Cancer Therapy – Bladder (FACT-BL), incidence of complications, rates of bladder tumor recurrence, results from the Self-Rating Anxiety Scale (SAS) and Self-Rating Depression Scale (SDS), as well as outcomes from the European Organization for Research and Treatment of Cancer Quality of Life Questionnaires (EORTC QLQ-C30 and QLQ-BLS24).

Results

The case management group showed higher overall treatment adherence (100 % vs 83.72 %, p = 0.013), calculated for all 47 patients who completed the one-year study period with no dropouts or exclusions due to protocol deviation, and lower complication rates during instillation (21.28 % vs 46.51 %, p = 0.011). FACT-BL scores in all four domains were higher in the case management group (all p < 0.05). SAS (41.77 vs 49.32, p < 0.001) and SDS (44.66 vs 47.82, p = 0.001) scores were lower. QLQ-BLS24 indicated reduced future concerns and improved gastrointestinal symptoms, while QLQ-C30 showed better cognitive, emotional, and social functioning. No difference in bladder tumor recurrence rates was observed (p > 0.05).

Conclusion

A structured case management model enhanced adherence, reduced complications, and improved quality of life for NMIBC patients receiving intravesical chemotherapy without negatively impacting short-term recurrence rates.
目的经尿道膀胱肿瘤切除术(TURBT)后非肌肉侵袭性膀胱癌(NMIBC)的成功治疗关键取决于膀胱内化疗的依从性。本研究评估病例管理模式对患者依从性和预后的影响。方法回顾性队列分析纳入2022年6月至2024年6月在TURBT术后接受膀胱化疗的NMIBC患者。受试者被分配到病例管理队列(n = 47)或常规护理队列(n = 43)。干预后6个月和12个月进行的评估包括治疗依从性、癌症治疗功能评估-膀胱(FACT-BL)评分、并发症发生率、膀胱肿瘤复发率、焦虑自评量表(SAS)和抑郁自评量表(SDS)的结果,以及欧洲癌症研究和治疗组织生活质量问卷(EORTC QLQ-C30和QLQ-BLS24)的结果。结果病例管理组显示了更高的总体治疗依从性(100% vs 83.72%, p = 0.013),所有47名患者完成了一年的研究期,没有因方案偏差而退出或排除,并且在注射期间并发症发生率较低(21.28% vs 46.51%, p = 0.011)。病例管理组在所有四个领域的FACT-BL得分均较高(p < 0.05)。SAS (41.77 vs 49.32, p < 0.001)和SDS (44.66 vs 47.82, p = 0.001)评分较低。QLQ-BLS24减少了对未来的担忧,改善了胃肠道症状,而QLQ-C30表现出更好的认知、情感和社交功能。两组膀胱肿瘤复发率无显著差异(p > 0.05)。结论结构化的病例管理模式提高了接受膀胱化疗的NMIBC患者的依从性,减少了并发症,改善了生活质量,而不会对短期复发率产生负面影响。
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引用次数: 0
Enhancing low-dose CT liver imaging with self-attention RRDB-ESRGAN: A SR approach for improved diagnostic accuracy 自我关注RRDB-ESRGAN增强低剂量CT肝脏成像:一种提高诊断准确性的SR方法
IF 2.5 4区 综合性期刊 Q2 MULTIDISCIPLINARY SCIENCES Pub Date : 2026-01-17 DOI: 10.1016/j.jrras.2025.102145
Wail M. Idress , Yuqian Zhao , Osama Ziad Shahin , Laeeq Aslam , Muhammad Asim , Mudasir Ahmad Wani , Kashish Ara Shakil
Computed tomography (CT) plays a critical role in diagnosing liver diseases by enabling detailed visualization of internal anatomical structures. However, to minimize radiation exposure, low-dose CT (LDCT) protocols are often adopted; these inevitably lead to increased image noise and reduced spatial resolution, which adversely affect diagnostic quality. To address these limitations, we propose a novel super-resolution (SR) framework based on an enhanced version of the Enhanced Super-Resolution Generative Adversarial Network (ESRGAN), specifically designed for LDCT liver imaging. Our method integrates Residual-in-Residual Dense Blocks (RRDBs) within the generator to effectively capture complex anatomical features and hierarchical textures. A self-attention module is incorporated to selectively emphasize diagnostically salient regions, facilitating more accurate restoration of critical structures. The discriminator network, trained using an adversarial learning strategy, guides the generator toward producing images with enhanced perceptual realism. We evaluate our Self-Attention Residual-in-Residual Dense Block ESRGAN (Self-Attention RRDB-ESRGAN) model using three publicly available datasets: the Liver Tumor Segmentation Challenge (LiTS17), 3DIRCADb, and the Medical Segmentation Decathlon (Task 03_Liver). Quantitative metrics, including peak signal-to-noise ratio (PSNR), structural similarity index measure (SSIM), and mean opinion score (MOS), demonstrate the superior performance of our model in restoring high-fidelity images from low-dose inputs. The Self-Attention RRDB-ESRGAN achieved an average PSNR of 41.579 dB and an SSIM of 0.9472, significantly outperforming existing methods, while experienced radiologists rated the perceptual quality with an average MOS of 4.05 out of 5. These findings highlight the effectiveness and clinical applicability of the proposed framework for enhancing LDCT liver images and improving diagnostic accuracy.
计算机断层扫描(CT)通过对肝脏内部解剖结构的详细可视化,在诊断肝脏疾病中起着至关重要的作用。然而,为了尽量减少辐射暴露,通常采用低剂量CT (LDCT)方案;这些不可避免地导致图像噪声增加和空间分辨率降低,从而对诊断质量产生不利影响。为了解决这些限制,我们提出了一种新的超分辨率(SR)框架,该框架基于增强型超分辨率生成对抗网络(ESRGAN)的增强版本,专门为LDCT肝脏成像设计。该方法将残差密集块(rrdb)集成到生成器中,以有效捕获复杂的解剖特征和分层纹理。一个自我关注模块被纳入选择性地强调诊断突出区域,促进更准确地恢复关键结构。鉴别器网络使用对抗学习策略进行训练,引导生成器生成具有增强感知真实感的图像。我们使用三个公开可用的数据集来评估我们的自注意残差密集块ESRGAN(自注意RRDB-ESRGAN)模型:肝脏肿瘤分割挑战(LiTS17)、3DIRCADb和医学分割十项竞赛(任务03_Liver)。定量指标,包括峰值信噪比(PSNR)、结构相似指数(SSIM)和平均意见评分(MOS),证明了我们的模型在从低剂量输入恢复高保真图像方面的卓越性能。自关注RRDB-ESRGAN的平均PSNR为41.579 dB, SSIM为0.9472,显著优于现有方法,而经验丰富的放射科医生对感知质量的平均MOS为4.05(满分5分)。这些发现强调了所提出的框架在增强LDCT肝脏图像和提高诊断准确性方面的有效性和临床适用性。
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引用次数: 0
Evaluation value of ultrasonic shear wave elastic imaging, MRI combined with ADC value in liver fibrosis degree of nonalcoholic fatty liver 超声剪切波弹性成像、MRI结合ADC值对非酒精性脂肪肝肝纤维化程度的评价价值
IF 2.5 4区 综合性期刊 Q2 MULTIDISCIPLINARY SCIENCES Pub Date : 2026-01-15 DOI: 10.1016/j.jrras.2025.102135
Yang Liu, Fei Teng, Yan Ding, Jian Zhou, Qibo Cai, Yang Shi, Qi Liu
To investigate the value of ultrasonic shear wave elastography (SWE), magnetic resonance imaging (MRI) and apparent diffusion coefficient (ADC) in evaluating the degree of liver fibrosis in nonalcoholic fatty liver disease (NAFLD).
150 patients with NAFLD were selected as the observation group, another 150 healthy subjects were selected as the control group. According to METAVIR score, the degree of liver fibrosis was divided into F0 stage, F1 stage, F2 stage, F3 stage and F4 stage. SWE, MRI and ADC values were detected in all subjects. Spearman correlation coefficient was used to analyze the correlation between each parameter and the stage of liver fibrosis.
The results of liver puncture pathology were the gold standard. Young's modulus and MRI-PDFF (Proton density fat fraction) in observation group were higher than those in control group, ADC was lower than those in control group (P < 0.05). Young's modulus and MRI-PDFF in F4 group were higher than those in F3, F2, F1 and F0 groups (P < 0.05), and ADC in F4 group was lower than that in F3, F2, F1 and F0 groups (P < 0.05), and the differences among all groups were statistically significant (P < 0.05). Young's modulus and MRI-PDFF were positively correlated with the degree of NAFLD liver fibrosis, while ADC was negatively correlated (r = 0.662, 0.542, −0.571, P < 0.05). The AUC value of Young's modulus, MRI-PDFF and ADC values in the evaluation of the degree of NAFLD liver fibrosis was higher than that of single detection (Z = 3.283, 3.276, 4.038, P < 0.05). The calibration curve and receiver operating characteristic curve (ROC) showed that the model had better predictive value, and the plotted decision curve (DCA) also showed obvious positive net benefit.
The combined determination of SWE, MRI and ADC has higher value in evaluating the degree of liver fibrosis in NAFLD. The nomogram model established by this method has good predictive value.
探讨超声横波弹性成像(SWE)、磁共振成像(MRI)和表观扩散系数(ADC)对非酒精性脂肪性肝病(NAFLD)肝纤维化程度的评价价值。选择150例NAFLD患者作为观察组,另选择150例健康受试者作为对照组。根据METAVIR评分将肝纤维化程度分为F0期、F1期、F2期、F3期和F4期。所有受试者均检测SWE、MRI和ADC值。采用Spearman相关系数分析各参数与肝纤维化分期的相关性。肝穿刺病理结果为金标准。观察组患者的杨氏模量、MRI-PDFF(质子密度脂肪分数)均高于对照组,ADC低于对照组(P < 0.05)。F4组的杨氏模量、MRI-PDFF高于F3、F2、F1、F0组(P < 0.05), F4组的ADC低于F3、F2、F1、F0组(P < 0.05),各组间差异有统计学意义(P < 0.05)。杨氏模量、MRI-PDFF与NAFLD肝纤维化程度呈正相关,ADC与NAFLD肝纤维化程度呈负相关(r = 0.662, 0.542, - 0.571, P < 0.05)。杨氏模量、MRI-PDFF和ADC值评价NAFLD肝纤维化程度的AUC值高于单一检测(Z = 3.283、3.276、4.038,P < 0.05)。校正曲线和受试者工作特征曲线(ROC)显示该模型具有较好的预测价值,绘制的决策曲线(DCA)也显示出明显的正净效益。SWE、MRI、ADC联合检测对NAFLD肝纤维化程度评价有较高价值。该方法建立的模态图模型具有较好的预测价值。
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引用次数: 0
A survey on recent Progress on Monte Carlo simulation methods in radiation detection 蒙特卡罗模拟方法在辐射探测中的最新进展综述
IF 2.5 4区 综合性期刊 Q2 MULTIDISCIPLINARY SCIENCES Pub Date : 2026-01-13 DOI: 10.1016/j.jrras.2025.102146
Nadyah Alanazi , Raghad Aljeraiwi , Maram Almutairi , Abdullah N. Alodhayb
Monte Carlo Simulations are methods used to simulate physical systems and evaluate physical properties that are extremely difficult to execute in real life. It is used as a golden standard tool for modeling complex radiation interactions with materials and for modeling complex detectors geometries. Such simulation methods designed for different particles transports such as protons, neutrons, and gamma-rays. In this review, we will focus on recent literature on using Monte Carlo Simulation in detecting radiations, focusing on GEANT, MCNP, and EGS toolkits highlighting their unique capabilities in simulating various particles and geometries with high accuracy, as well as recent advancements in enhancing their performance including high-performance computing integration, variance reduction techniques, and hybrid modeling approaches that combine Monte Carlo simulations with deterministic or AI-based techniques. The review outlines recent Monte Carlo simulation applications such as medical physics, particle physics, and environmental monitoring, underlining the adaptability and future potentials of Monte Carlo simulation in advanced radiation detection systems.
蒙特卡罗模拟是用来模拟物理系统和评估物理特性的方法,在现实生活中很难执行。它被用作模拟与材料的复杂辐射相互作用和模拟复杂探测器几何形状的黄金标准工具。这种模拟方法是为不同的粒子传输设计的,如质子、中子和伽马射线。在这篇综述中,我们将重点介绍最近关于使用蒙特卡罗模拟检测辐射的文献,重点介绍GEANT, MCNP和EGS工具包,重点介绍它们在高精度模拟各种粒子和几何形状方面的独特能力,以及在增强其性能方面的最新进展,包括高性能计算集成,方差减少技术,以及将蒙特卡罗模拟与确定性或基于人工智能的技术相结合的混合建模方法。本文概述了蒙特卡罗模拟在医学物理、粒子物理和环境监测等方面的最新应用,强调了蒙特卡罗模拟在先进辐射探测系统中的适应性和未来潜力。
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引用次数: 0
KLK5 promotes anoikis resistance in non-small cell lung cancer by activating PI3K/AKT signaling pathway KLK5通过激活PI3K/AKT信号通路促进非小细胞肺癌的anoikis耐药
IF 2.5 4区 综合性期刊 Q2 MULTIDISCIPLINARY SCIENCES Pub Date : 2026-01-13 DOI: 10.1016/j.jrras.2026.102162
Lei Zhang , Qingqing Sun , Qingyong Cai , Mingqiang Shen , Zhijun Zhu , Tengfang Zhang , Baolei Liang , Jinjiao Zhang

Background

Metastasis and recurrence remain the principal causes of mortality in non-small cell lung cancer (NSCLC) patients. A critical prerequisite for tumor cell invasion and metastasis is the development of resistance to anoikis. In NSCLC, high levels of KLK5 are linked to lymphatic metastasis and unfavorable patient survival. This study was designed to investigate the role of KLK5 in anoikis and hypothesized that KLK5 promotes NSCLC metastasis by conferring anoikis resistance via the PI3K/AKT pathway.

Methods

We established and characterized an anoikis-resistant stable cell line, AR-H1299. KLK5 expression in these cells was measured using RT-qPCR and Western blot. Functional assessments of AR-H1299 cells, including CCK-8 assay, colony formation assay, flow cytometry, wound healing assay, and Transwell assay, were performed, and the levels of epithelial-mesenchymal transition (EMT) and metastasis signaling-related proteins were examined. The mechanism by which KLK5 confers anoikis resistance was further investigated through Western blot analysis and functional rescue experiments.

Results

Our results show that KLK5 expression is closely associated with anoikis resistance in NSCLC cells. Genetic knockdown of KLK5 inhibited, while its overexpression enhanced, the proliferation, migration, invasion, and EMT process of AR-H1299 cells. Mechanistic studies revealed that KLK5 promotes the expression of downstream apoptotic regulators Bcl-2 and Bad by activating the PI3K/AKT pathway. Rescue experiments confirmed that the PI3K/AKT inhibitor LY294002 could counteract the pro-metastatic effects induced by KLK5 upregulation.

Conclusion

This study elucidates a previously unreported mechanism by which KLK5 confers anoikis resistance through the PI3K/AKT signaling pathway to promote metastasis in NSCLC.
背景:转移和复发仍然是非小细胞肺癌(NSCLC)患者死亡的主要原因。肿瘤细胞侵袭和转移的一个关键先决条件是对肿瘤产生耐药性。在非小细胞肺癌中,高水平的KLK5与淋巴转移和不利的患者生存有关。本研究旨在探讨KLK5在anoikis中的作用,并假设KLK5通过PI3K/AKT通路赋予anoikis抗性,从而促进NSCLC转移。方法建立一株抗异臭稳定细胞系AR-H1299,并对其进行鉴定。采用RT-qPCR和Western blot检测KLK5在这些细胞中的表达。对AR-H1299细胞进行功能评估,包括CCK-8实验、集落形成实验、流式细胞术、伤口愈合实验和Transwell实验,并检测上皮-间质转化(EMT)和转移信号相关蛋白的水平。通过Western blot分析和功能拯救实验进一步研究了KLK5赋予anoikis抗性的机制。结果KLK5表达与非小细胞肺癌耐药密切相关。KLK5基因敲低抑制AR-H1299细胞的增殖、迁移、侵袭和EMT过程,而过表达增强。机制研究表明,KLK5通过激活PI3K/AKT通路,促进下游凋亡调节因子Bcl-2和Bad的表达。救援实验证实PI3K/AKT抑制剂LY294002可以抵消KLK5上调诱导的促转移作用。本研究阐明了一种以前未报道的机制,即KLK5通过PI3K/AKT信号通路赋予anoikis抗性,从而促进NSCLC的转移。
{"title":"KLK5 promotes anoikis resistance in non-small cell lung cancer by activating PI3K/AKT signaling pathway","authors":"Lei Zhang ,&nbsp;Qingqing Sun ,&nbsp;Qingyong Cai ,&nbsp;Mingqiang Shen ,&nbsp;Zhijun Zhu ,&nbsp;Tengfang Zhang ,&nbsp;Baolei Liang ,&nbsp;Jinjiao Zhang","doi":"10.1016/j.jrras.2026.102162","DOIUrl":"10.1016/j.jrras.2026.102162","url":null,"abstract":"<div><h3>Background</h3><div>Metastasis and recurrence remain the principal causes of mortality in non-small cell lung cancer (NSCLC) patients. A critical prerequisite for tumor cell invasion and metastasis is the development of resistance to anoikis. In NSCLC, high levels of KLK5 are linked to lymphatic metastasis and unfavorable patient survival. This study was designed to investigate the role of KLK5 in anoikis and hypothesized that KLK5 promotes NSCLC metastasis by conferring anoikis resistance via the PI3K/AKT pathway.</div></div><div><h3>Methods</h3><div>We established and characterized an anoikis-resistant stable cell line, AR-H1299. KLK5 expression in these cells was measured using RT-qPCR and Western blot. Functional assessments of AR-H1299 cells, including CCK-8 assay, colony formation assay, flow cytometry, wound healing assay, and Transwell assay, were performed, and the levels of epithelial-mesenchymal transition (EMT) and metastasis signaling-related proteins were examined. The mechanism by which KLK5 confers anoikis resistance was further investigated through Western blot analysis and functional rescue experiments.</div></div><div><h3>Results</h3><div>Our results show that KLK5 expression is closely associated with anoikis resistance in NSCLC cells. Genetic knockdown of KLK5 inhibited, while its overexpression enhanced, the proliferation, migration, invasion, and EMT process of AR-H1299 cells. Mechanistic studies revealed that KLK5 promotes the expression of downstream apoptotic regulators Bcl-2 and Bad by activating the PI3K/AKT pathway. Rescue experiments confirmed that the PI3K/AKT inhibitor LY294002 could counteract the pro-metastatic effects induced by KLK5 upregulation.</div></div><div><h3>Conclusion</h3><div>This study elucidates a previously unreported mechanism by which KLK5 confers anoikis resistance through the PI3K/AKT signaling pathway to promote metastasis in NSCLC.</div></div>","PeriodicalId":16920,"journal":{"name":"Journal of Radiation Research and Applied Sciences","volume":"19 1","pages":"Article 102162"},"PeriodicalIF":2.5,"publicationDate":"2026-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145976945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hybrid quantum-classical convolutional neural networks for multiclass lung X-ray image classification 混合量子经典卷积神经网络在肺部x射线图像分类中的应用
IF 2.5 4区 综合性期刊 Q2 MULTIDISCIPLINARY SCIENCES Pub Date : 2026-01-13 DOI: 10.1016/j.jrras.2026.102165
Ariiq Islam Alfajri , Tony Sumaryada , Sitti Yani , Duong Thanh Tai , Nissren Tamam , Abdelmoneim Sulieman

Purpose

This study explores the integration of quantum computing with classical convolutional neural networks (CNNs) to improve the classification of lung X-ray images into three diagnostic categories: normal, lung opacity, and viral pneumonia.

Methods

A dataset of 3475 lung X-ray images was split into training (80 %) and validation (20 %) subsets. Hybrid models combining classical CNN layers with quantum convolutional layers were developed using various combinations of quantum gates, including Rotation-X/Y and Pauli-X/Y/Z. Data augmentation techniques were applied to mitigate overfitting. Model performance was evaluated using accuracy, precision, recall, and F1-score.

Results

The classical CNN model achieved the highest accuracy of 91 %. Among the quantum-enhanced models, the combination of Rotation-X and Pauli-Z gates produced the best results, reaching an accuracy of 87 %. While quantum integration introduced a slight decrease in accuracy, it demonstrated comparable performance across multiple gate configurations.

Conclusion

Hybrid quantum-classical CNNs show promise for medical image classification, with certain quantum gate combinations offering competitive performance. Further optimization of quantum parameters and multi-qubit interactions may enhance their future applicability in diagnostic imaging.
目的:探讨量子计算与经典卷积神经网络(cnn)的融合,将肺x线图像分为正常、肺不透明和病毒性肺炎三种诊断类型。方法将3475张肺x线图像数据集分为训练子集(80%)和验证子集(20%)。结合经典CNN层和量子卷积层的混合模型采用了不同的量子门组合,包括旋转门- x /Y和保利- x /Y/Z。采用数据增强技术来减轻过拟合。使用准确性、精密度、召回率和f1评分来评估模型的性能。结果经典CNN模型的准确率最高,达到91%。在量子增强模型中,旋转- x和保利- z门的组合产生了最好的结果,达到了87%的精度。虽然量子集成引入的精度略有下降,但它在多个栅极配置中表现出相当的性能。结论混合量子经典cnn在医学图像分类中有很好的应用前景,某些量子门组合具有一定的竞争力。进一步优化量子参数和多量子比特相互作用可能会增强它们在诊断成像中的适用性。
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引用次数: 0
The Hamilton-crosser thermal conductivity model in the quaternary nanofluid flow with second-order slip condition 二阶滑移条件下第四系纳米流体的Hamilton-crosser导热模型
IF 2.5 4区 综合性期刊 Q2 MULTIDISCIPLINARY SCIENCES Pub Date : 2026-01-10 DOI: 10.1016/j.jrras.2025.102142
Hazirah Mohd Azmi , Norihan Md Arifin , Haliza Rosali , Siti Suzilliana Putri Mohamed Isa
Nanofluids, formed by dispersing nanoparticles into conventional base fluids, have gained significant attention as advanced heat transfer media in various sectors, including automotive, aerospace, nuclear reactors, biomedical systems, etc. Their enhanced thermophysical properties and particularly improved thermal conductivity, which make them superior to traditional fluids for high-efficiency thermal management. To accurately estimate the thermal conductivity of nanofluids, several theoretical models have been proposed, among which the Hamilton-Crosser (HC) model is widely adopted. This model extends Maxwell's classical theory by incorporating particle shape factors, providing more accurate predictions for fluids containing non-spherical or clustered nanoparticles. In the field of fluid mechanics, boundary layer flows influenced by magnetohydrodynamics (MHD) and thermal radiation are of increasing relevance in systems subjected to magnetic fields and high heat loads, such as in magnetic cooling, plasma processing and solar energy applications. According to this problem statement, this paper provides a numerical solution for the mathematical modelling of the MHD radiative water-based nanofluid flow. This nanofluid contains a combination of four nanoparticles: alumina, copper, graphene and silicon dioxide, which represents a quaternary hybrid nanofluid system. The mathematical modelling was initiated with the partial differential equations (PDEs) and finalised by ordinary differential equations (ODEs). The transformations from PDEs to ODEs simplify the mathematical model for numerical analysis, which can be done by using similarity transformations. The resulting ODEs are solved using MATLAB's built-in bvp4c solver. Key physical quantities for the profiles (velocity and temperature) and the quantities measured for the flow and thermal characteristics (skin friction coefficient and local Nusselt number) are graphically illustrated and described. The results show that the quaternary case produces the highest heat transfer rate compared to the nanofluid case, which has the lowest number of nanoparticle types (nanofluid case). In addition, the cylindrical shape is proven to have the highest local Nusselt number value for the stretching boundary case, while the spherical shape produces the highest local Nusselt number value for the shrinking boundary. Meanwhile, the magnetic field, thermal radiation, slip condition and projected angle at the sheet influence the distribution of the profile and physical parameters.
纳米流体是将纳米颗粒分散到传统的基础流体中形成的,作为先进的传热介质,在汽车、航空航天、核反应堆、生物医学系统等各个领域得到了广泛的关注。它们增强了热物理特性,特别是提高了导热性,这使得它们在高效热管理方面优于传统流体。为了准确估计纳米流体的热导率,人们提出了几种理论模型,其中广泛采用的是Hamilton-Crosser (HC)模型。该模型通过纳入颗粒形状因素扩展了麦克斯韦的经典理论,为含有非球形或簇状纳米颗粒的流体提供了更准确的预测。在流体力学领域,受磁流体动力学(MHD)和热辐射影响的边界层流动在磁场和高热负荷的系统中越来越重要,例如在磁冷却、等离子体处理和太阳能应用中。根据这一问题陈述,本文给出了MHD辐射水基纳米流体流动数学建模的数值解。这种纳米流体包含四种纳米颗粒的组合:氧化铝、铜、石墨烯和二氧化硅,代表了一种四元混合纳米流体系统。数学建模由偏微分方程开始,由常微分方程结束。从偏微分方程到偏微分方程的转换简化了数值分析的数学模型,这可以通过相似变换来实现。使用MATLAB内置的bvp4c求解器求解得到的ode。剖面的关键物理量(速度和温度)和流量和热特性的测量量(表面摩擦系数和局部努塞尔数)用图形表示和描述。结果表明,与纳米流体情况相比,季元情况下的传热速率最高,而纳米流体情况下的纳米颗粒类型最少;此外,证明了圆柱形状在拉伸边界情况下具有最高的局部努塞尔数值,而球面形状在收缩边界情况下具有最高的局部努塞尔数值。同时,磁场、热辐射、滑移情况和薄片上的投影角度对剖面分布和物性参数都有影响。
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引用次数: 0
SIRT7-mediated desuccinylation of PRMT5 activates the ERK1/2-VEGF-C axis to promote lymphangiogenesis in gastric cancer sirt7介导的PRMT5去琥珀酰化激活ERK1/2-VEGF-C轴,促进胃癌淋巴管生成
IF 2.5 4区 综合性期刊 Q2 MULTIDISCIPLINARY SCIENCES Pub Date : 2026-01-08 DOI: 10.1016/j.jrras.2025.102120
Hongpeng Zhao, Zhihua Liang, Feng Li, Haihua Yu, Kai Li, Bo Liu

Background

Lymphangiogenesis plays a significant role in tumor metastasis, making it a critical target for cancer therapies. PRMT5, an oncogene involved in various cellular processes, and SIRT7, a desuccinylase, regulate this process in gastric cancer (GC) through complex signaling pathways. However, the specific role of PRMT5 in tumor-induced lymphangiogenesis remains largely unexplored. This study investigates the role of SIRT7 in modulating PRMT5 expression and its impact on lymphangiogenesis through the ERK1/2 signaling pathway in GC.

Methods

All functional assays were performed using human lymphatic endothelial cells (HLECs). HLECs were subjected to PRMT5 and SIRT7 knockdown or overexpression via lentiviral transfection. Cell proliferation was evaluated by CCK-8 assay, tube formation was assessed using Matrigel assays, and protein expression was detected by Western blotting. VEGF-C secretion was measured by ELISA, and Co-immunoprecipitation was performed to examine the interaction between SIRT7 and PRMT5. The ERK1/2 signaling pathway was analyzed to elucidate downstream mechanisms.

Results

PRMT5 knockdown inhibited lymphangiogenesis and reduced VEGF-C expression, while SIRT7 suppression increased PRMT5 levels, enhancing endothelial cell proliferation and tube formation. Western blotting showed that PRMT5 activates the ERK1/2 pathway, which is essential for VEGF-C regulation. Co-immunoprecipitation further confirmed a direct interaction between SIRT7 and PRMT5, supporting the regulatory link between these proteins.

Conclusions

We identify the SIRT7/PRMT5/ERK1/2/VEGF-C axis as a novel and key regulator of lymphangiogenesis in GC, with significant potential therapeutic implications.
背景淋巴管生成在肿瘤转移中起着重要作用,是肿瘤治疗的重要靶点。PRMT5是一种参与多种细胞过程的癌基因,SIRT7是一种去琥珀酰化酶,通过复杂的信号通路调节胃癌(GC)的这一过程。然而,PRMT5在肿瘤诱导的淋巴管生成中的具体作用在很大程度上仍未被探索。本研究探讨SIRT7在GC中通过ERK1/2信号通路调节PRMT5表达及其对淋巴管生成的影响。方法采用人淋巴内皮细胞(HLECs)进行功能检测。通过慢病毒转染,HLECs遭受PRMT5和SIRT7的敲低或过表达。CCK-8法检测细胞增殖,Matrigel法检测管形成,Western blotting法检测蛋白表达。ELISA法检测VEGF-C分泌,并用共免疫沉淀法检测SIRT7与PRMT5的相互作用。我们分析了ERK1/2信号通路以阐明其下游机制。结果sprmt5基因敲低可抑制淋巴管生成,降低VEGF-C表达,而SIRT7基因敲低可提高PRMT5水平,促进内皮细胞增殖和小管形成。Western blotting结果显示,PRMT5激活ERK1/2通路,这对VEGF-C调控至关重要。共免疫沉淀进一步证实了SIRT7和PRMT5之间的直接相互作用,支持了这些蛋白之间的调控联系。我们发现SIRT7/PRMT5/ERK1/2/VEGF-C轴是GC中淋巴管生成的一个新的关键调节因子,具有重要的潜在治疗意义。
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引用次数: 0
Process analysis for strengthening radiation safety practices in operating theatre 加强手术室辐射安全实践的过程分析
IF 2.5 4区 综合性期刊 Q2 MULTIDISCIPLINARY SCIENCES Pub Date : 2026-01-08 DOI: 10.1016/j.jrras.2026.102164
Sahal Alotaibi , Sultan Alamri , Ahmad Joman Alghamdi , Nahla L. Faizo , Hamid Osman , Mohammad AlTalhi , Hasan Althumali , Mansour Almalki , Hatem Alotaibi , Mohammed Alghoraibi , Thamer Aljuaid , Dalia Alharthi , Abdulelah Alasmari
Radiation safety in operating theatres is critical due to the growing use of radiation-emitting equipment in surgical specialties. While individual knowledge and compliance have been widely studied, limited research has focused on the systemic processes influencing radiation protection implementation. This study aimed to analyze radiation safety processes across healthcare roles to identify factors that facilitate or hinder effective protection. A cross-sectional survey was conducted among 212 healthcare professionals (116 technologists, 57 nurses, 26 surgeons, and 13 anesthesiologists) working in operating theatres with radiation-emitting equipment. The survey assessed process effectiveness in seven areas: safety checks, responsibility clarity, equipment accessibility, dosimeter use, communication, learning from incidents, and interdepartmental coordination. Statistical analysis included descriptive statistics, Kruskal-Wallis tests, and content analysis. Ethical approval was obtained, and the sample size was justified based on statistical power considerations. Significant variations in process effectiveness were found across roles, especially in equipment accessibility (p = 0.0039) and communication (p = 0.0201). Anesthesiologists reported higher effectiveness scores, while surgeons reported lower scores. Only 25 % of participants reported "always accessible" radiation protection equipment, and 30.7 % cited insufficient training as a major barrier. Team communication was the top enabler (44.8 %), while time pressure (28.8 %) and lack of awareness (29.2 %) were key barriers. Radiation safety in operating theatres is a systems issue requiring a focus on organizational processes, not just individual compliance. Addressing systemic factors, such as equipment accessibility and communication, is crucial for improving radiation safety.

Keyords

Radiation protection, Operation theatres, Safety, Saudi Arabia.
由于外科专业越来越多地使用辐射设备,手术室的辐射安全至关重要。虽然对个人知识和依从性进行了广泛的研究,但有限的研究集中在影响辐射防护实施的系统过程上。本研究旨在分析各个医疗保健角色的辐射安全过程,以确定促进或阻碍有效防护的因素。对在有放射设备的手术室工作的212名医疗保健专业人员(116名技术人员、57名护士、26名外科医生和13名麻醉师)进行了横断面调查。该调查从七个方面评估了流程的有效性:安全检查、责任明确、设备可及性、剂量计的使用、沟通、从事故中吸取教训和部门间协调。统计分析包括描述性统计、Kruskal-Wallis检验和内容分析。获得了伦理批准,并根据统计功率考虑了样本量的合理性。过程有效性在不同角色之间存在显著差异,特别是在设备可及性(p = 0.0039)和沟通(p = 0.0201)方面。麻醉师报告的有效性得分较高,而外科医生报告的有效性得分较低。只有25%的参与者报告说“总是可以获得”辐射防护设备,30.7%的人认为培训不足是主要障碍。团队沟通是最大的促成因素(44.8%),而时间压力(28.8%)和缺乏意识(29.2%)是主要障碍。手术室的辐射安全是一个系统问题,需要关注组织流程,而不仅仅是个人合规。解决诸如设备可及性和通信等系统性因素对于改善辐射安全至关重要。关键词:辐射防护;手术室;安全;
{"title":"Process analysis for strengthening radiation safety practices in operating theatre","authors":"Sahal Alotaibi ,&nbsp;Sultan Alamri ,&nbsp;Ahmad Joman Alghamdi ,&nbsp;Nahla L. Faizo ,&nbsp;Hamid Osman ,&nbsp;Mohammad AlTalhi ,&nbsp;Hasan Althumali ,&nbsp;Mansour Almalki ,&nbsp;Hatem Alotaibi ,&nbsp;Mohammed Alghoraibi ,&nbsp;Thamer Aljuaid ,&nbsp;Dalia Alharthi ,&nbsp;Abdulelah Alasmari","doi":"10.1016/j.jrras.2026.102164","DOIUrl":"10.1016/j.jrras.2026.102164","url":null,"abstract":"<div><div>Radiation safety in operating theatres is critical due to the growing use of radiation-emitting equipment in surgical specialties. While individual knowledge and compliance have been widely studied, limited research has focused on the systemic processes influencing radiation protection implementation. This study aimed to analyze radiation safety processes across healthcare roles to identify factors that facilitate or hinder effective protection. A cross-sectional survey was conducted among 212 healthcare professionals (116 technologists, 57 nurses, 26 surgeons, and 13 anesthesiologists) working in operating theatres with radiation-emitting equipment. The survey assessed process effectiveness in seven areas: safety checks, responsibility clarity, equipment accessibility, dosimeter use, communication, learning from incidents, and interdepartmental coordination. Statistical analysis included descriptive statistics, Kruskal-Wallis tests, and content analysis. Ethical approval was obtained, and the sample size was justified based on statistical power considerations. Significant variations in process effectiveness were found across roles, especially in equipment accessibility (p = 0.0039) and communication (p = 0.0201). Anesthesiologists reported higher effectiveness scores, while surgeons reported lower scores. Only 25 % of participants reported \"always accessible\" radiation protection equipment, and 30.7 % cited insufficient training as a major barrier. Team communication was the top enabler (44.8 %), while time pressure (28.8 %) and lack of awareness (29.2 %) were key barriers. Radiation safety in operating theatres is a systems issue requiring a focus on organizational processes, not just individual compliance. Addressing systemic factors, such as equipment accessibility and communication, is crucial for improving radiation safety.</div></div><div><h3>Keyords</h3><div>Radiation protection, Operation theatres, Safety, Saudi Arabia.</div></div>","PeriodicalId":16920,"journal":{"name":"Journal of Radiation Research and Applied Sciences","volume":"19 1","pages":"Article 102164"},"PeriodicalIF":2.5,"publicationDate":"2026-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145924666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Performance assessment of commonly used active radiation protection dosimeters for individual and area workplace monitoring 个人和区域工作场所监测常用主动辐射防护剂量计的性能评价
IF 2.5 4区 综合性期刊 Q2 MULTIDISCIPLINARY SCIENCES Pub Date : 2026-01-07 DOI: 10.1016/j.jrras.2026.102159
Jelena Vlahović , Nikola Kržanović , Miloš Živanović , Ivana Stojanović , Luka Bakrač , Argiro Boziari , Miloš Đaletić , Ana Fernandes , Liviu-Cristian Mihailescu , Erinc Reyhanoglu , Siarhei Saroka , Teemu Siiskonen , Jana Šmoldasová , Vladimir Sochor , Maria do Ceu Ferreira , Nataša Todorović

Background

Improvement in radiation protection practice may be achieved by acquisition of reliable and accurate dosimetry data. Use of dosimeters with known properties provides insight into their performance in real radiation fields encountered in radiation monitoring practice.

Aim

Performance evaluation in a wide range of radiation conditions provides insight into dosimeter behaviour, providing input for revision, update and harmonization of IEC type testing standards.

Methods

A total of 32 active dosimeters were investigated, of which 26 are used for area workplace, and 6 for individual monitoring. Dosimeter performance was evaluated against the IEC 60846–1:2009 standard for portable workplace and environmental meters and monitors and the IEC 61526:2024 standard for active personal dosimeters in a wide range of photon energies, angles of incidence and dose equivalent rates. Performance was examined beyond the minimum rated range: 33.3 keV–1.25 MeV photon energy; (0°; ±75°) angle of incidence for personal dosimeters and (0°; ±120° with 180°) for area dosimeters; 3 μSv h−1 – 7 Sv h−1 dose rate range. In addition, dosimeter short-term stability and overload properties were investigated.

Results

State-of-the-art and commonly used dosimeters complied with the standard defined limits of variation with respect to the manufacturer stated specifications. Some dosimeters had significantly lower variations in terms of relative response than the current standard stated requirements.

Conclusion

Potential update of the relevant IEC type testing standards was considered, with the possibility of introducing two distinct dosimeter classes, one of which would comply with reduced limits of variation.
背景:通过获得可靠和准确的剂量学数据,可以改善辐射防护工作。使用具有已知特性的剂量计可以深入了解其在辐射监测实践中遇到的实际辐射领域中的性能。AimPerformance在各种辐射条件下的评估提供了对剂量计行为的深入了解,为IEC类型测试标准的修订,更新和协调提供了输入。方法共调查32台活性剂量计,其中26台用于区域工作场所,6台用于个人监测。根据IEC 60846-1:2009便携式工作场所和环境仪表和监视器标准以及IEC 61526:2024有源个人剂量计标准,在广泛的光子能量,入射角和剂量当量率范围内对剂量计的性能进行了评估。在最小额定范围内:33.3 kv - 1.25 MeV光子能量;个人剂量计的入射角为(0°;±75°),区域剂量计的入射角为(0°;±120°和180°);3 μSv h−1 ~ 7 μSv h−1剂量率范围。此外,还研究了剂量计的短期稳定性和过载性能。结果最先进的和常用的剂量计符合标准规定的变异限和制造商说明的规格。在相对反应方面,有些剂量计的变化比现行标准规定的要求要小得多。结论考虑了相关IEC型式测试标准的潜在更新,可能引入两种不同的剂量计类别,其中一种将符合降低的变异限值。
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引用次数: 0
期刊
Journal of Radiation Research and Applied Sciences
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