Mei-Ji Sun , Rui Zhao , Min Wen , Chun-Wang Meng , Hai-Guo Su , Fu-Xin Mi , Cheng Peng , Juan Liu , Liang Xiong
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引用次数: 0
Abstract
Two novel phenolic glycosides, 3-methoxyacetophenone-4-O-β-D-apiofuranosyl-(1→2)-β-D-glucopyranoside (1) and 3-methoxyacetophenone-4-O-β-D-(5′′-O-p-hydroxybenzoyl)-apiofuranosyl-(1→2)-β-D-glucopyranoside (2), along with one known analogue (3), were isolated from the ethyl acetate extract of Cyathula officinalis. Extensive spectroscopic analyses and chemical methods determined their structures and absolute configurations. The relaxant effects of the isolated compounds on uterine contractions induced by oxytocin were investigated using a rat uterine smooth muscle contraction model. The results indicated that both compounds 1 and 2 had inhibitory effects on oxytocin-induced uterine smooth muscle contraction.
期刊介绍：
Phytochemistry Letters invites rapid communications on all aspects of natural product research including:
• Structural elucidation of natural products
• Analytical evaluation of herbal medicines
• Clinical efficacy, safety and pharmacovigilance of herbal medicines
• Natural product biosynthesis
• Natural product synthesis and chemical modification
• Natural product metabolism
• Chemical ecology
• Biotechnology
• Bioassay-guided isolation
• Pharmacognosy
• Pharmacology of natural products
• Metabolomics
• Ethnobotany and traditional usage
• Genetics of natural products
Manuscripts that detail the isolation of just one new compound are not substantial enough to be sent out of review and are out of scope. Furthermore, where pharmacology has been performed on one new compound to increase the amount of novel data, the pharmacology must be substantial and/or related to the medicinal use of the producing organism.
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