Resting-State fMRI to Map Language Function for Surgical Planning in Patients With Brain Tumors: A Feasibility Study

IF 2.3 4区医学 Q3 CLINICAL NEUROLOGY Journal of Neuroimaging Pub Date : 2025-02-25 DOI:10.1111/jon.70027

Annalisa Bozzano, Laura Barletta, Stefano Caneva, Monica Truffelli, Elisa Bennicelli, Giacomo Rebella, Gianluigi Zona, Lucio Castellan

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Abstract

Background and Purpose

In neurosurgery, functional MRI is crucial for preoperative planning to obtain the cortical cortex map of language areas. This preliminary work involved analyzing the functional MRIs of 20 oncological patients. Our question is if resting-state functional MRI (rs-fMRI) can replace standard task-based functional MRI (tb-fMRI) in routine clinical applications. The aim of this challenge is to determine if rs-fMRI is as effective as tb-fMRI and to develop a systematic approach for the extraction of a cortical language map.

Methods

We started by analyzing our rs-fMRI images and validated the correct mapping of language regions using an independent components analysis approach; then, we used the analysis of connectivity networks to compare the two techniques.

Results

The regions identified in rs-fMRI align with established medical knowledge; a comparison of rs-fMRI and tb-fMRI reveals that the four language regions—Broca's and Wernicke's areas in both hemispheres—exhibit activation in both techniques; furthermore, we highlighted that rs-fMRI reveals more comprehensive details about functional connectivity in contrast to tb-fMRI.

Conclusions

rs-MRI and tb-MRI provide similar levels of efficacy in revealing the functional areas of the brain for preoperative mapping when a lesion lies in areas related to language; thus, both techniques can be utilized for this goal. Based on this, we developed an rs-fMRI processing pipeline for clinical usage and applied it to a patient outside the study.

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来源期刊

Journal of Neuroimaging 医学-核医学

CiteScore

4.70

自引率

0.00%

发文量

117

审稿时长

6-12 weeks

期刊介绍： Start reading the Journal of Neuroimaging to learn the latest neurological imaging techniques. The peer-reviewed research is written in a practical clinical context, giving you the information you need on: MRI CT Carotid Ultrasound and TCD SPECT PET Endovascular Surgical Neuroradiology Functional MRI Xenon CT and other new and upcoming neuroscientific modalities.The Journal of Neuroimaging addresses the full spectrum of human nervous system disease, including stroke, neoplasia, degenerating and demyelinating disease, epilepsy, tumors, lesions, infectious disease, cerebral vascular arterial diseases, toxic-metabolic disease, psychoses, dementias, heredo-familial disease, and trauma.Offering original research, review articles, case reports, neuroimaging CPCs, and evaluations of instruments and technology relevant to the nervous system, the Journal of Neuroimaging focuses on useful clinical developments and applications, tested techniques and interpretations, patient care, diagnostics, and therapeutics. Start reading today!