Catalase-like Nanozyme-Hybrid Hydrogels Utilizing Endogenous ROS as an Oxygen Source To Synergically Regulate Oxidative Stress and Hypoxia for Enhanced Diabetic Wound Healing
Yehao Chen , Bo Yuan , Zhixuan Yang , Shifeng Yan , Kaixuan Ren , Qingmeng Pi , Yan Liu , Jingbo Yin
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Abstract
High levels of reactive oxygen species (ROS) and hypoxia in diabetic wounds significantly hinder the healing process. In this work, a kind of catalase-like nanozyme-hybrid hydrogel was developed to explore the potential of harnessing endogenous excessive ROS as an oxygen source to synergistically regulate oxidative stress and hypoxia, thereby enhancing diabetic wound healing. The hydrogels exhibited rapid degradation and controlled release of ferrihydrite nanozymes in response to oxidative stress, which continuously catalyzed the decomposition of H2O2 to generate oxygen, effectively scavenging ROS and reducing the risk of local oxygen toxicity. The hydrogels relieved intracellular oxidative stress and the hypoxic microenvironment simultaneously in vitro. The hydrogel dressings effectively inhibited oxidative damage at wound sites, promoted epidermis formation and collagen deposition, and significantly accelerated wound healing in db/db mice. Therefore, the catalase-like nanozyme-hybrid hydrogels represent a promising strategy for diabetic wound dressings, addressing both oxidative stress and hypoxia to improve healing outcomes.
期刊介绍：
Biomacromolecules is a leading forum for the dissemination of cutting-edge research at the interface of polymer science and biology. Submissions to Biomacromolecules should contain strong elements of innovation in terms of macromolecular design, synthesis and characterization, or in the application of polymer materials to biology and medicine.
Topics covered by Biomacromolecules include, but are not exclusively limited to: sustainable polymers, polymers based on natural and renewable resources, degradable polymers, polymer conjugates, polymeric drugs, polymers in biocatalysis, biomacromolecular assembly, biomimetic polymers, polymer-biomineral hybrids, biomimetic-polymer processing, polymer recycling, bioactive polymer surfaces, original polymer design for biomedical applications such as immunotherapy, drug delivery, gene delivery, antimicrobial applications, diagnostic imaging and biosensing, polymers in tissue engineering and regenerative medicine, polymeric scaffolds and hydrogels for cell culture and delivery.
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