Fabrication of multifunctional hydrogels based on tannic acid-coated nanocrystalline cellulose.

Abstract

Composite hydrogels are promising for wound healing, but combining strong antimicrobial properties with mechanical performance remains challenging due to potential disruptions in cross-linking. This study presented a one-step method to incorporate tannic acid-coated cellulose nanocrystals (TA@CNC) into polyacrylamide hydrogels. The resulting composite hydrogel exhibited superior mechanical strength, environmental stability, and antimicrobial and antioxidant activities. TA@CNC served as a dynamic reinforcement within the porous network, enhancing mechanical stability. The hydrogel also demonstrated sustained and repeatable adhesion, attributed to the moisture-resistant properties of tannic acid. This work offers valuable insights for the design of multifunctional composite hydrogels, with the developed materials showing great potential for use in medical dressings due to their stretchability, self-adhesion, and antimicrobial and antioxidant properties.