Maternal environmental enrichment affects the corpora lutea and progesterone levels in pregnant mice.

IF 4.6 2区医学 Q2 ENDOCRINOLOGY & METABOLISM Frontiers in Endocrinology Pub Date : 2025-02-10 eCollection Date: 2025-01-01 DOI:10.3389/fendo.2025.1483893

Fernanda Luz De la Cruz Borthiry, Jimena Soledad Beltrame, Julieta Aylen Schander, Aime Florencia Silva, Fernanda Parborell, Ana María Franchi, María Laura Ribeiro

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Abstract

Introduction: Maternal lifestyle impacts reproductive performance. Previously, we demonstrated that maternal environmental enrichment promotes pregnancy success in BALB/c mice. As progesterone regulates gestation, we decided to study the effect of maternal environmental enrichment on ovarian physiology during early gestation.

Methods: For this, six-week-old female mice were housed in enriched or control cages for six weeks and then mated with control fertile males. Females with a mucus plug were returned to their respective control or enriched cages. Pregnant mice were euthanized on day 7 of pregnancy, and ovaries and progesterone levels were investigated.

Results: Hematoxylin and eosin slices showed no differences in the area (μm²) of the ovaries between control and enriched females. Also, the number of primordial, primary, preantral, antral, and atretic follicles was similar for both treatments. However, the number and area (μm²) of corpora lutea were increased in the ovaries from the enriched group. Moreover, enriched females presented higher progesterone serum levels and increased 3β-HSD expression.

Discussion: Therefore, maternal environmental enrichment regulates ovarian physiology, and this could promote the benefits previously reported.

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母体环境富集影响孕鼠黄体和黄体酮水平。

前言：产妇的生活方式影响生殖性能。之前，我们证明了母体环境富集促进BALB/c小鼠妊娠成功。由于黄体酮调节妊娠，我们决定研究母体环境富集对妊娠早期卵巢生理的影响。方法：将6周龄的雌性小鼠分别置于强化或对照笼子中6周，然后与对照的有生育能力的雄性小鼠交配。粘液堵塞的雌性被送回各自的对照笼子或强化笼子。在妊娠第7天对孕鼠实施安乐死，观察其卵巢和孕酮水平。结果：苏木精和伊红切片显示对照组和富组雌鼠卵巢面积（μm2）无差异。此外，原始卵泡、原发卵泡、前腔卵泡、前腔卵泡和闭锁卵泡的数量在两种治疗中相似。而黄体数量和黄体面积（μm2）均明显增加。此外，富集后的雌性血清黄体酮水平升高，3β-HSD表达增加。讨论：因此，母体环境富集调节卵巢生理，这可能促进先前报道的益处。

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来源期刊

Frontiers in Endocrinology Medicine-Endocrinology, Diabetes and Metabolism

CiteScore

5.70

自引率

9.60%

发文量

3023

审稿时长

14 weeks

期刊介绍： Frontiers in Endocrinology is a field journal of the "Frontiers in" journal series. In today’s world, endocrinology is becoming increasingly important as it underlies many of the challenges societies face - from obesity and diabetes to reproduction, population control and aging. Endocrinology covers a broad field from basic molecular and cellular communication through to clinical care and some of the most crucial public health issues. The journal, thus, welcomes outstanding contributions in any domain of endocrinology. Frontiers in Endocrinology publishes articles on the most outstanding discoveries across a wide research spectrum of Endocrinology. The mission of Frontiers in Endocrinology is to bring all relevant Endocrinology areas together on a single platform.