Kevin Hua MD , Mike Cummings MD , Miriam Bernatik MD , Benno Brinkhaus MD, PhD , Taras Usichenko MD, PhD , Stefan N. Willich MD, PhD , Carmen Scheibenbogen MD, PhD , Joanna Dietzel MD
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引用次数: 0
Abstract
Background
The number of randomized controlled trials (RCTs) using auricular stimulation (AS) techniques, such as transauricular vagus nerve stimulation, auricular electrostimulation, auricular acupuncture, and acupressure in experimental and clinical settings has increased markedly over the last three decades. This systematic review evaluates the effects of AS on biomarkers of inflammation and stress responses.
Materials and Methods
The following data bases were searched: MEDLINE (PubMed), EMBASE, Cochrane Central Register of Controlled Trials (CENTRAL), ISI Web of Science, and Scopus Data base. Data collection and analysis were conducted independently by two reviewers. Quality and risk assessments of the included studies were performed, and a meta-analysis of the effects of the most frequently assessed biomarkers was conducted using RevMan statistical software.
Results
A total of 1122 patients and healthy volunteers from 27 RCTs were included in this systematic review; 81% of the participants were female, with a median age of 51 years. Pooled data of 18 studies showed a significant effect of AS regarding a reduction of serum C-reactive protein, tumor necrosis factor-α, interleukin (IL)-6, and IL-10. Although IL-4, IL1β, cortisol, substance P and calcitonin gene-related peptide, and adrenocorticotropic hormone did not show any changes, salivary amylase increased under AS.
Conclusions
The influence of inflammatory cytokines seems to be mediated by AS. More research is needed to investigate the effects of AS on the immunologic system in addition to its clinical significance in high-quality RCT.
背景：在过去的三十年中，在实验和临床环境中使用耳穴刺激（AS）技术（如经耳迷走神经刺激、耳穴电刺激、耳穴针灸和指压）的随机对照试验（RCTs）的数量显著增加。本系统综述评估了AS对炎症和应激反应的生物标志物的影响。材料和方法：检索以下数据库：MEDLINE （PubMed）、EMBASE、Cochrane Central Register of Controlled Trials （Central）、ISI Web of Science和Scopus database。数据收集和分析由两名审稿人独立进行。对纳入的研究进行质量和风险评估，并使用RevMan统计软件对最常评估的生物标志物的影响进行荟萃分析。结果：本系统综述共纳入27项随机对照试验的1122例患者和健康志愿者；81%的参与者是女性，中位年龄为51岁。18项研究的汇总数据显示，AS对血清c反应蛋白、肿瘤坏死因子-α、白细胞介素(IL)-6和IL-10的降低有显著影响。虽然IL-4、il - 1β、皮质醇、P物质和降钙素基因相关肽、促肾上腺皮质激素没有变化，但唾液淀粉酶升高。结论：炎性细胞因子的影响可能是由AS介导的。除了在高质量RCT中的临床意义外，还需要更多的研究来探讨AS对免疫系统的影响。
期刊介绍：
Neuromodulation: Technology at the Neural Interface is the preeminent journal in the area of neuromodulation, providing our readership with the state of the art clinical, translational, and basic science research in the field. For clinicians, engineers, scientists and members of the biotechnology industry alike, Neuromodulation provides timely and rigorously peer-reviewed articles on the technology, science, and clinical application of devices that interface with the nervous system to treat disease and improve function.
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