UFMylation: Exploring a lesser known post translational modification

IF 4.1 2区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Plant Science Pub Date : 2025-02-22 DOI:10.1016/j.plantsci.2025.112435

Rohit Sharma , Oceania Chirom , Abdul Mujib , Manoj Prasad , Ashish Prasad

引用次数: 0

Abstract

Ubiquitination is a highly conserved post-translational modification (PTM) in which ubiquitin (Ub) is covalently attached to substrate proteins resulting in the alteration of protein structure, function, and stability. Another class of PTM mediated by ubiquitin-like proteins (UBLs) has gained significant attention among researchers in recent years. This article focuses on one such UBL-mediated PTM i.e. UFMylation. The enzymatic mechanism of UFMylation is similar to ubiquitination, involving three steps regulated by three different enzymes. In plants, reports suggest that UFMylation is predominantly involved in maintaining ER homeostasis including ER-phagy. However, studies related to this PTM are limited and future studies might reveal other molecular pathways regulated by UFMylation.

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UFMylation：探索一种鲜为人知的翻译后修饰。

泛素化是一种高度保守的翻译后修饰（PTM），泛素（Ub）共价附着在底物蛋白上，导致蛋白质结构、功能和稳定性的改变。近年来，一类由泛素样蛋白（ubitin -like proteins, UBLs）介导的PTM引起了研究人员的极大关注。本文主要讨论一种由ubl介导的PTM，即UFMylation。ufmyation的酶机制类似于泛素化，涉及三个步骤，由三种不同的酶调节。在植物中，报告表明ufmyation主要参与维持内质网稳态，包括内质网吞噬。然而，与该PTM相关的研究有限，未来的研究可能会揭示ufmyation调节的其他分子途径。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Plant Science 生物-生化与分子生物学

CiteScore

9.10

自引率

1.90%

发文量

322

审稿时长

33 days

期刊介绍： Plant Science will publish in the minimum of time, research manuscripts as well as commissioned reviews and commentaries recommended by its referees in all areas of experimental plant biology with emphasis in the broad areas of genomics, proteomics, biochemistry (including enzymology), physiology, cell biology, development, genetics, functional plant breeding, systems biology and the interaction of plants with the environment. Manuscripts for full consideration should be written concisely and essentially as a final report. The main criterion for publication is that the manuscript must contain original and significant insights that lead to a better understanding of fundamental plant biology. Papers centering on plant cell culture should be of interest to a wide audience and methods employed result in a substantial improvement over existing established techniques and approaches. Methods papers are welcome only when the technique(s) described is novel or provides a major advancement of established protocols.