{"title":"Bridging the Gap: Advancing Pharmacogenetic Testing Through Comprehensive Implementation and Evaluation Strategies.","authors":"Sara Rogers, Patrick J Silva, Kenneth Ramos","doi":"10.1097/FTD.0000000000001314","DOIUrl":null,"url":null,"abstract":"<p><strong>Abstract: </strong>Pharmacogenomics (PGx) enhances drug therapy by tailoring treatment to individual genetic profiles, thereby improving safety and efficacy. However, the integration of PGx into clinical practice, particularly in hospitals, faces significant challenges, including limited testing services, variant coverage, and inconsistent guidelines. A recent review, \"Implementation and Evaluation Strategies of Pharmacogenetic Testing in Hospital Settings,\" highlights these challenges and current strategies. Sustaining PGx programs requires ongoing education, support, the integration of advanced technologies, and financial sustainability. Addressing inconsistent insurance coverage, developing standardized methodologies, and implementing clear policies are crucial for widespread adoption, advancement of personalized medicine, and improvement of patient care in hospital settings.</p>","PeriodicalId":23052,"journal":{"name":"Therapeutic Drug Monitoring","volume":" ","pages":""},"PeriodicalIF":2.8000,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Therapeutic Drug Monitoring","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1097/FTD.0000000000001314","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"MEDICAL LABORATORY TECHNOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Abstract: Pharmacogenomics (PGx) enhances drug therapy by tailoring treatment to individual genetic profiles, thereby improving safety and efficacy. However, the integration of PGx into clinical practice, particularly in hospitals, faces significant challenges, including limited testing services, variant coverage, and inconsistent guidelines. A recent review, "Implementation and Evaluation Strategies of Pharmacogenetic Testing in Hospital Settings," highlights these challenges and current strategies. Sustaining PGx programs requires ongoing education, support, the integration of advanced technologies, and financial sustainability. Addressing inconsistent insurance coverage, developing standardized methodologies, and implementing clear policies are crucial for widespread adoption, advancement of personalized medicine, and improvement of patient care in hospital settings.
期刊介绍：
Therapeutic Drug Monitoring is a peer-reviewed, multidisciplinary journal directed to an audience of pharmacologists, clinical chemists, laboratorians, pharmacists, drug researchers and toxicologists. It fosters the exchange of knowledge among the various disciplines–clinical pharmacology, pathology, toxicology, analytical chemistry–that share a common interest in Therapeutic Drug Monitoring. The journal presents studies detailing the various factors that affect the rate and extent drugs are absorbed, metabolized, and excreted. Regular features include review articles on specific classes of drugs, original articles, case reports, technical notes, and continuing education articles.
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