Toxicological Assessment of Ketamine in Juvenile Zebrafish (Danio rerio).

IF 3.9 3区环境科学与生态学 Q2 ENVIRONMENTAL SCIENCES Toxics Pub Date : 2025-01-24 DOI:10.3390/toxics13020082

Yin Tang, Kang Yang, Jintao Xu, Yangkai Qiu, Liang Meng, Sen Zhao

{"title":"Toxicological Assessment of Ketamine in Juvenile Zebrafish (Danio rerio).","authors":"Yin Tang, Kang Yang, Jintao Xu, Yangkai Qiu, Liang Meng, Sen Zhao","doi":"10.3390/toxics13020082","DOIUrl":null,"url":null,"abstract":"This study investigates the toxic effects of ketamine on juvenile zebrafish, driven by increasing concerns over ketamine's prevalence and its potential neurotoxic effects that may disrupt behavior and metabolism. Employing a high-throughput behavior tracking system, the research analyzed the locomotor activity of 6-day post-fertilization (6 dpf) zebrafish exposed to various concentrations of ketamine. The integration of behavioral analysis with metabolic profiling was a notable innovation, as it establishes a comprehensive understanding of ketamine's effects on both acute behavioral inhibition and metabolic responses. The findings reveal that ketamine exposure significantly inhibits locomotor activity in juvenile zebrafish, with these effects becoming more pronounced at higher concentrations. Additionally, the detection of normethketamine, the primary metabolite of ketamine, using UPLC-LTQ/Orbitrap HRMS, confirms the zebrafish's ability to metabolize the drug. This underscores the utility of zebrafish as a model organism for studying the impact of ketamine on behavior and metabolism, providing valuable insights that may extend to other vertebrates.","PeriodicalId":23195,"journal":{"name":"Toxics","volume":"13 2","pages":""},"PeriodicalIF":3.9000,"publicationDate":"2025-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11860410/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Toxics","FirstCategoryId":"93","ListUrlMain":"https://doi.org/10.3390/toxics13020082","RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"ENVIRONMENTAL SCIENCES","Score":null,"Total":0}

引用次数: 0

Abstract

This study investigates the toxic effects of ketamine on juvenile zebrafish, driven by increasing concerns over ketamine's prevalence and its potential neurotoxic effects that may disrupt behavior and metabolism. Employing a high-throughput behavior tracking system, the research analyzed the locomotor activity of 6-day post-fertilization (6 dpf) zebrafish exposed to various concentrations of ketamine. The integration of behavioral analysis with metabolic profiling was a notable innovation, as it establishes a comprehensive understanding of ketamine's effects on both acute behavioral inhibition and metabolic responses. The findings reveal that ketamine exposure significantly inhibits locomotor activity in juvenile zebrafish, with these effects becoming more pronounced at higher concentrations. Additionally, the detection of normethketamine, the primary metabolite of ketamine, using UPLC-LTQ/Orbitrap HRMS, confirms the zebrafish's ability to metabolize the drug. This underscores the utility of zebrafish as a model organism for studying the impact of ketamine on behavior and metabolism, providing valuable insights that may extend to other vertebrates.

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

求助全文

约1分钟内获得全文去求助

来源期刊

Toxics Chemical Engineering-Chemical Health and Safety

CiteScore

4.50

自引率

10.90%

发文量

681

审稿时长

6 weeks

期刊介绍： Toxics (ISSN 2305-6304) is an international, peer-reviewed, open access journal which provides an advanced forum for studies related to all aspects of toxic chemicals and materials. It publishes reviews, regular research papers, and short communications. Our aim is to encourage scientists to publish their experimental and theoretical results in detail. There is, therefore, no restriction on the maximum length of the papers, although authors should write their papers in a clear and concise way. The full experimental details must be provided so that the results can be reproduced. Electronic files or software regarding the full details of calculations and experimental procedure can be deposited as supplementary material, if it is not possible to publish them along with the text.