Uncovering the Potential Link Between Polychlorinated Biphenyls and Cardiovascular Diseases: A Comprehensive Analysis.

IF 4.1 3区环境科学与生态学 Q2 ENVIRONMENTAL SCIENCES Toxics Pub Date : 2025-01-22 DOI:10.3390/toxics13020071

Jingyu Liu, Qiuli Shan, Yang Yang, Wenxing He

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Abstract

Background: A family of persistent organic pollutants, known as polychlorinated biphenyls (PCBs), are extensively found in the environment and may be harmful to the cardiovascular system. Systematic reviews and meta-analyses are required to thoroughly evaluate the association between PCB exposure and cardiovascular disease (CVDs), despite the fact that studies on the subject have produced inconsistent results.

Objective: The purpose of this study was to investigate the relationship between PCBs exposure and cardiovascular disease risk in order to provide more conclusive data to promote public health actions.

Methods: The studies that met the inclusion criteria were screened out using the databases PubMed, Web of Science, ScienceDirect, and Cochrane Library. The comprehensive effect size (OR) was calculated using the random-effects model; the study's heterogeneity was analyzed using I² statistics; the major reasons of heterogeneity were identified using subgroup analysis; and publication bias graphically was measured using the Egger's test.

Results: A meta-analysis of 11 studies revealed that total PCBs (OR = 1.56, 95% CI: 1.20-1.75), non-dioxin-like PCBs (NDL-PCBs) (OR = 1.33, 95% CI: 1.15-1.53), and dioxin-like PCBs (DL-PCBs) (OR = 1.31, 95% CI: 1.10-1.57) were all found to be positively associated with the risk of cardiovascular disease. Subgroup analysis revealed that study type, biomaterials, and literature quality were the most significant drivers of variation. Furthermore, certain PCB homologues, such as non-dioxin-like (NDL)-PCB153 and dioxin-like (DL)-PCB118, are highly related with cardiovascular disease.

Conclusions: According to this meta-analysis, exposure to PCBs may increase the risk of cardiovascular disease. Notwithstanding major drawbacks, our results emphasize the significance of lowering exposure to PCBs and offering a solid theoretical basis for public health initiatives.

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揭示多氯联苯与心血管疾病之间的潜在联系：一项综合分析。

背景：被称为多氯联苯（PCBs）的一类持久性有机污染物广泛存在于环境中，可能对心血管系统有害。尽管有关多氯联苯暴露与心血管疾病（cvd）之间的研究结果不一致，但仍需要系统评价和荟萃分析来彻底评估两者之间的关系。目的：探讨多氯联苯暴露与心血管疾病风险的关系，为促进公共卫生行动提供更有说服力的数据。方法：使用PubMed、Web of Science、ScienceDirect和Cochrane Library数据库筛选符合纳入标准的研究。采用随机效应模型计算综合效应量（OR）；采用I2统计分析研究的异质性；采用亚组分析确定异质性的主要原因；用Egger’s检验测量发表偏倚。结果：对11项研究的荟萃分析显示，总多氯联苯（OR = 1.56, 95% CI: 1.20-1.75）、非二恶英样多氯联苯（OR = 1.33, 95% CI: 1.15-1.53）和二恶英样多氯联苯（OR = 1.31, 95% CI: 1.10-1.57）均与心血管疾病的风险呈正相关。亚组分析显示，研究类型、生物材料和文献质量是影响变异的最重要因素。此外，某些PCB同系物，如非二恶英样(NDL)-PCB153和二恶英样(DL)-PCB118，与心血管疾病高度相关。结论：根据这项荟萃分析，暴露于多氯联苯可能会增加心血管疾病的风险。尽管存在重大缺陷，但我们的研究结果强调了降低多氯联苯暴露的重要性，并为公共卫生倡议提供了坚实的理论基础。

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来源期刊

Toxics Chemical Engineering-Chemical Health and Safety

CiteScore

4.50

自引率

10.90%

发文量

681

审稿时长

6 weeks

期刊介绍： Toxics (ISSN 2305-6304) is an international, peer-reviewed, open access journal which provides an advanced forum for studies related to all aspects of toxic chemicals and materials. It publishes reviews, regular research papers, and short communications. Our aim is to encourage scientists to publish their experimental and theoretical results in detail. There is, therefore, no restriction on the maximum length of the papers, although authors should write their papers in a clear and concise way. The full experimental details must be provided so that the results can be reproduced. Electronic files or software regarding the full details of calculations and experimental procedure can be deposited as supplementary material, if it is not possible to publish them along with the text.