{"title":"Can exclusive breastfeeding in the first 4 months reduce food allergy? A retrospective questionnaire study.","authors":"Nadira Musallam, Meital Almog, Roni Wagner, Larisa Epov, Vika Dor, Aharon Kessel","doi":"10.1016/j.anai.2025.02.011","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>IgE-mediated food allergy is a major global health concern. While early introduction of allergenic foods and breastfeeding are potential preventive strategies, the role of breast milk in reducing food allergy incidence remains inconclusive.</p><p><strong>Objective: </strong>We aimed to investigate the impact of exclusive breastfeeding for the first four months compared to partial breastfeeding or cow's milk formula (CMF) on the development of IgE-mediated food allergies (FAs) in an Israeli cohort.</p><p><strong>Methods: </strong>A cross-sectional online survey of 3,030 mothers with infants aged 6-24 months collected data on early feeding practices, allergen introduction, atopic conditions, and family history. It documented suspected allergic reactions, symptoms, and diagnostic procedures.</p><p><strong>Results: </strong>Of 3,030 surveyed mothers, 2,920 provided complete feeding data for the first 4 months. Among these, 39.0% exclusively breastfed, 12.1% used CMF, and 48.9% partially breastfed. There were 392 infants with FAs, totaling 480 cases involving cow's milk, sesame, egg, or peanut. Of these cases, 122 (25.4%) were in the breastfeeding group, and 358 (74.6%) were in the other groups. Exclusively breastfed infants had lower odds of egg (OR=0.53), sesame (OR=0.58), and peanut (OR=0.53) allergies compared to others. The interaction between feeding patterns and atopic dermatitis (AD) related to these FAs was insignificant. Exposure to CMF in the nursery and exclusively breastfed was associated with higher odds of developing cow's milk allergy. Delayed exposure to sesame in infants with AD was linked to increased odds of developing sesame allergy.</p><p><strong>Conclusion: </strong>Exclusive breastfeeding may reduce the odds of developing IgE-mediated FA, regardless of AD status.</p>","PeriodicalId":50773,"journal":{"name":"Annals of Allergy Asthma & Immunology","volume":" ","pages":""},"PeriodicalIF":5.8000,"publicationDate":"2025-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Annals of Allergy Asthma & Immunology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.anai.2025.02.011","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ALLERGY","Score":null,"Total":0}
引用次数: 0
Abstract
Background: IgE-mediated food allergy is a major global health concern. While early introduction of allergenic foods and breastfeeding are potential preventive strategies, the role of breast milk in reducing food allergy incidence remains inconclusive.
Objective: We aimed to investigate the impact of exclusive breastfeeding for the first four months compared to partial breastfeeding or cow's milk formula (CMF) on the development of IgE-mediated food allergies (FAs) in an Israeli cohort.
Methods: A cross-sectional online survey of 3,030 mothers with infants aged 6-24 months collected data on early feeding practices, allergen introduction, atopic conditions, and family history. It documented suspected allergic reactions, symptoms, and diagnostic procedures.
Results: Of 3,030 surveyed mothers, 2,920 provided complete feeding data for the first 4 months. Among these, 39.0% exclusively breastfed, 12.1% used CMF, and 48.9% partially breastfed. There were 392 infants with FAs, totaling 480 cases involving cow's milk, sesame, egg, or peanut. Of these cases, 122 (25.4%) were in the breastfeeding group, and 358 (74.6%) were in the other groups. Exclusively breastfed infants had lower odds of egg (OR=0.53), sesame (OR=0.58), and peanut (OR=0.53) allergies compared to others. The interaction between feeding patterns and atopic dermatitis (AD) related to these FAs was insignificant. Exposure to CMF in the nursery and exclusively breastfed was associated with higher odds of developing cow's milk allergy. Delayed exposure to sesame in infants with AD was linked to increased odds of developing sesame allergy.
Conclusion: Exclusive breastfeeding may reduce the odds of developing IgE-mediated FA, regardless of AD status.
期刊介绍：
Annals of Allergy, Asthma & Immunology is a scholarly medical journal published monthly by the American College of Allergy, Asthma & Immunology. The purpose of Annals is to serve as an objective evidence-based forum for the allergy/immunology specialist to keep up to date on current clinical science (both research and practice-based) in the fields of allergy, asthma, and immunology. The emphasis of the journal will be to provide clinical and research information that is readily applicable to both the clinician and the researcher. Each issue of the Annals shall also provide opportunities to participate in accredited continuing medical education activities to enhance overall clinical proficiency.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
