{"title":"Long-term blood sugar control with smart insulin crystals","authors":"","doi":"10.1038/s41565-025-01871-x","DOIUrl":null,"url":null,"abstract":"Insulin crystals coated with a thin, porous membrane with electrical potential-sensitive channels — named i-crystal — show glucose- and ketone-responsive insulin release. Owing to their high drug-loading content and slow, zero-order insulin release kinetics, i-crystal can regulate the blood glucose level for more than 1 month in mice models with type 1 diabetes.","PeriodicalId":18915,"journal":{"name":"Nature nanotechnology","volume":"24 1","pages":""},"PeriodicalIF":38.1000,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nature nanotechnology","FirstCategoryId":"88","ListUrlMain":"https://doi.org/10.1038/s41565-025-01871-x","RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"MATERIALS SCIENCE, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0
Abstract
Insulin crystals coated with a thin, porous membrane with electrical potential-sensitive channels — named i-crystal — show glucose- and ketone-responsive insulin release. Owing to their high drug-loading content and slow, zero-order insulin release kinetics, i-crystal can regulate the blood glucose level for more than 1 month in mice models with type 1 diabetes.
期刊介绍：
Nature Nanotechnology is a prestigious journal that publishes high-quality papers in various areas of nanoscience and nanotechnology. The journal focuses on the design, characterization, and production of structures, devices, and systems that manipulate and control materials at atomic, molecular, and macromolecular scales. It encompasses both bottom-up and top-down approaches, as well as their combinations.
Furthermore, Nature Nanotechnology fosters the exchange of ideas among researchers from diverse disciplines such as chemistry, physics, material science, biomedical research, engineering, and more. It promotes collaboration at the forefront of this multidisciplinary field. The journal covers a wide range of topics, from fundamental research in physics, chemistry, and biology, including computational work and simulations, to the development of innovative devices and technologies for various industrial sectors such as information technology, medicine, manufacturing, high-performance materials, energy, and environmental technologies. It includes coverage of organic, inorganic, and hybrid materials.
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