{"title":"CTCF and cohesin mediate the chromatin–speckle ground-state association","authors":"","doi":"10.1038/s41594-024-01466-5","DOIUrl":null,"url":null,"abstract":"The association of chromatin with nuclear speckles is crucial in gene regulation. Here, cell biology and genomic methods revealed that the chromatin factors CTCF and cohesin are key organizers of chromatin–speckle interactions. This organization enhanced speckle-proximal gene activation, linking nuclear architecture to gene regulation and developmental disorders.","PeriodicalId":18822,"journal":{"name":"Nature structural & molecular biology","volume":"29 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nature structural & molecular biology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1038/s41594-024-01466-5","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
The association of chromatin with nuclear speckles is crucial in gene regulation. Here, cell biology and genomic methods revealed that the chromatin factors CTCF and cohesin are key organizers of chromatin–speckle interactions. This organization enhanced speckle-proximal gene activation, linking nuclear architecture to gene regulation and developmental disorders.
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