{"title":"CTCF and cohesin mediate the chromatin–speckle ground-state association","authors":"","doi":"10.1038/s41594-024-01466-5","DOIUrl":null,"url":null,"abstract":"The association of chromatin with nuclear speckles is crucial in gene regulation. Here, cell biology and genomic methods revealed that the chromatin factors CTCF and cohesin are key organizers of chromatin–speckle interactions. This organization enhanced speckle-proximal gene activation, linking nuclear architecture to gene regulation and developmental disorders.","PeriodicalId":49141,"journal":{"name":"Nature Structural & Molecular Biology","volume":"32 6","pages":"964-965"},"PeriodicalIF":10.1000,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nature Structural & Molecular Biology","FirstCategoryId":"99","ListUrlMain":"https://www.nature.com/articles/s41594-024-01466-5","RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
The association of chromatin with nuclear speckles is crucial in gene regulation. Here, cell biology and genomic methods revealed that the chromatin factors CTCF and cohesin are key organizers of chromatin–speckle interactions. This organization enhanced speckle-proximal gene activation, linking nuclear architecture to gene regulation and developmental disorders.
期刊介绍：
Nature Structural & Molecular Biology is a comprehensive platform that combines structural and molecular research. Our journal focuses on exploring the functional and mechanistic aspects of biological processes, emphasizing how molecular components collaborate to achieve a particular function. While structural data can shed light on these insights, our publication does not require them as a prerequisite.
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