Perspective: Emerging challenges for a future ADNI

IF 11.1 1区医学 Q1 CLINICAL NEUROLOGY Alzheimer's & Dementia Pub Date : 2025-02-26 DOI:10.1002/alz.14534

Zaven Khachaturian, Maria C. Carrillo, Ara S. Khachaturian

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Abstract

In the last two decades, the Alzheimer's Disease Neuroimaging Initiative (ADNI) has significantly advanced our understanding, technologies, and methods for detecting and diagnosing Alzheimer's disease and related dementias. This perspective proposes repurposing ADNI to address emerging research and healthcare challenges. The focus would shift toward early detection of cognitive impairment, discovering new interventions, evaluating non-pharmacological treatments, adopting a public health approach, and enrolling a diverse international cohort. Key elements of this new model include emphasizing vascular-metabolic factors, leveraging biomarkers, and enhancing computational capabilities. By reimagining ADNI's mission and framework, the initiative may be better poised to tackle the evolving complexities of dementia research and improve patient outcomes through a more comprehensive, multidisciplinary approach.

Highlights

ADNI should be repurposed for early detection and intervention in cognitive decline.
This would emphasize vascular-metabolic factors and biomarkers in dementia research.
It advocates for non-pharmacological evaluations and a public health approach.
It promotes international cohort studies and enhanced computational capacity.

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展望：未来ADNI面临的新挑战

在过去的二十年中，阿尔茨海默病神经影像学倡议（ADNI）显著提高了我们对检测和诊断阿尔茨海默病和相关痴呆的理解、技术和方法。这一观点建议重新利用ADNI来应对新兴的研究和医疗保健挑战。重点将转向早期发现认知障碍，发现新的干预措施，评估非药物治疗，采用公共卫生方法，并招募不同的国际队列。这个新模型的关键要素包括强调血管代谢因素、利用生物标志物和增强计算能力。通过重新构想ADNI的使命和框架，该倡议可能会更好地应对痴呆症研究不断发展的复杂性，并通过更全面、多学科的方法改善患者的治疗效果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Alzheimer's & Dementia 医学-临床神经学

CiteScore

14.50

自引率

5.00%

发文量

299

审稿时长

3 months

期刊介绍： Alzheimer's & Dementia is a peer-reviewed journal that aims to bridge knowledge gaps in dementia research by covering the entire spectrum, from basic science to clinical trials to social and behavioral investigations. It provides a platform for rapid communication of new findings and ideas, optimal translation of research into practical applications, increasing knowledge across diverse disciplines for early detection, diagnosis, and intervention, and identifying promising new research directions. In July 2008, Alzheimer's & Dementia was accepted for indexing by MEDLINE, recognizing its scientific merit and contribution to Alzheimer's research.