A colorimetric/SERS dual-mode sensor based on ferric ion-dopamine@Au–Ag-Au Janus NPs for acrylamide determination in baked goods

IF 5.3 2区化学 Q1 CHEMISTRY, ANALYTICAL Microchimica Acta Pub Date : 2025-02-27 DOI:10.1007/s00604-025-07051-x

Yutong Wang, Yizhi Liu, Xiao Liang, Zhiyuan Liu, Yaling Yang

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Abstract

This study successfully developed a colorimetric/SERS dual-mode sensor for determining acrylamide in baked goods based on the excellent peroxidase-like activity and Raman activity of Fe-PHS@Au–Ag-Au Janus NPs. In colorimetric mode, the thiol-ene Michael addition between acrylamide (AA) and glutathione (GSH) efficiently eliminates GSH-induced peroxidase-like activity inhibition. The peroxidase-like activity of Fe-PHS@Au–Ag-Au Janus NPs gradually recovered, and the blue color of the solution gradually deepened with the increase in AA dosage. In surface-enhanced Raman spectroscopy (SERS), Apt-Fe-PHS@Au–Ag-Au Janus NPs can selectively capture AA and bind specifically, leading to the dissociation of Apt and Fe-PHS@Au–Ag-Au Janus NPs. The Raman activity of Apt-Fe-PHS@Au–Ag-Au Janus NPs decreases due to the dissociation of Apt. The dual-mode sensor was utilized for the determination of acrylamide in the concentrations range from 0.05 to 20 µg·L⁻¹ with detection limits of 0.06 µg·L⁻¹ (SERS) and 0.01 µg·L⁻¹ (colorimetric). The recovery in baked samples was between 91.0 and 108.0%.

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基于ion-dopamine@Au -Ag-Au Janus NPs铁的比色/SERS双模传感器测定烘焙食品中的丙烯酰胺

本研究基于Fe-PHS@Au -Ag-Au Janus NPs优异的过氧化物酶样活性和拉曼活性，成功开发了用于测定烘焙食品中丙烯酰胺的比色/SERS双模传感器。在比色模式下，丙烯酰胺（AA）和谷胱甘肽（GSH）之间的巯基Michael加成有效地消除了GSH诱导的过氧化物酶样活性抑制。随着AA用量的增加，Fe-PHS@Au -Ag-Au Janus NPs的过氧化物酶样活性逐渐恢复，溶液的蓝色逐渐加深。在表面增强拉曼光谱（SERS）中，Apt-Fe-PHS@Au -Ag-Au Janus NPs可以选择性捕获AA并特异性结合，导致Apt和Fe-PHS@Au -Ag-Au Janus NPs解离。Apt-Fe-PHS@Au -Ag-Au Janus NPs的拉曼活性由于Apt的解离而降低。双模传感器用于测定浓度范围为0.05 ~ 20µg·L−1的丙烯酰胺，检测限为0.06µg·L−1 （SERS）和0.01µg·L−1（比色法）。焙烧样品的回收率在91.0 ~ 108.0%之间。图形抽象

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文献相关原料

公司名称

产品信息

阿拉丁

Sodium citrate

阿拉丁

3,3′,5,5′-tetramethylbenzidine

阿拉丁

Acrylamide

阿拉丁

Dopamine hydrochloride

阿拉丁

Hydrogen tetrachloroaurate hydrate

阿拉丁

Ferric nitrate hydrate

来源期刊

Microchimica Acta 化学-分析化学

CiteScore

9.80

自引率

5.30%

发文量

410

审稿时长

2.7 months

期刊介绍： As a peer-reviewed journal for analytical sciences and technologies on the micro- and nanoscale, Microchimica Acta has established itself as a premier forum for truly novel approaches in chemical and biochemical analysis. Coverage includes methods and devices that provide expedient solutions to the most contemporary demands in this area. Examples are point-of-care technologies, wearable (bio)sensors, in-vivo-monitoring, micro/nanomotors and materials based on synthetic biology as well as biomedical imaging and targeting.